Objective To study the benzylphenethylamine alkaloids from the bulbs and flowers of Lycoris radiata (L′ Her.) Herb. Methods Alkaloids were isolated by various column chromatographic methods and their structures were identified by spectral data. Results Fifteen known benzylphenethylamine alkaloids were isolated and identified as lycoramine (1), O-demethyllycoramine (2), N-demethyllycoramine (3), galanthamine (4), lycorine (5), caranine (6), ungminorine (7), narciclasine (8), 5-hydroxy-10-O-demethyl-homolycorine (9), hippeastrine (10), ungerine (11), hippeastrine N-oxide (12), O-demethylhaemanthamine (13), haemanthidine (14), and 8-demethoxyhostasine (15). Conclusions Compound 15 was firstly isolated from Amaryllidaceae, compounds 3, 6, 9 and 11 were firstly reported from the genus Lycoris, and compounds 2, 7 and 14 were isolated from L. radiata for the first time, and the 13C-NMR data of compouds 3, 7 and 12 were firstly repoted in the present study. Furthermore, the galasine-type alkaloid was isolated from the genus Lycoris for the frist time.
