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Archive > Volume 4 Issue 3 > 2012,4(3):183-188. DOI:10.3969/j.issn.1674-6384.2012.03.002 Prev Next

Original articles

Triterpene Glycosides from Sea Cucumber Holothuria scabra with Cytotoxic Activity

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    摘要:


    Abstract:
    Objective To study the new triterpene glycosides from sea cucumber Holothuria scabra with cytotoxic activity. Methods Triterpene glycosides from H. scabra were separated and purified by chromatography on DA-101, silica gel, and reversed-phase silica gel column, as well as RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Results Three triterpene glycosides were identified as scabraside D (1), fuscocineroside C (2), and 24-dehydroechinoside A (3). Their inhibition on P-388, A549, MKN-28, HCT116, and MCF-7 cells were significant. Conclusion Scabraside D (1) is a new triterpene glycoside, and compounds 2 and 3 are isolated from H. scabra for the first time. The glycosides 1－3 show the in vitro cytotoxicity against five human tumor cell lines in comparison to 10-hydroxycamptothecin.

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    Project Supported:
    National High-Tech Research and Development Project (863 Project, 2006AA09Z417) and National Natural Science Foundation of China (20772155)

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