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Archive > Volume 4 Issue 3 > 2012,4(3):237-244. DOI:10.3969/j.issn.1674-6384.2012.03.011 Prev Next

Original articles

Standardization and Identification of Minor Components of Silymarin (MK-001)

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    摘要:


    Abstract:
    Objective To develop a highly effective HPLC method for standardization of silymarin and for characterization of minor components, which has not been reported previously. Methods An HPLC fingerprinting method and 1H-NMR spectroscopy were employed to provide assurance for a standardized silymarin product (MK-001). Results A total of 18 marker compounds were identified and characterized including ten flavonolignans and eight small molecules including adenine, adenosine, uridine, and 3,5,7-trihydroxychromone which were first isolated and characterized from silymarin. The HPLC fingerprinting method and 1H-NMR had been established for complete assignments of HPLC peaks with intensity over 1.0%. Conclusion The successfully established HPLC fingerprinting method and 1H-NMR could be applied for the standardization of commercial silymarin products. MK-001 represents the first standardized silymarin with the highest content of flavonolignans ( > 90%).

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    Project Supported:
    NIH/NCCAM-STTR-R42-AT-00766

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