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Archive > Volume 10 Issue 1 > 2018,10(1):95-98. DOI:10.1016/j.chmed.2017.12.001 Prev Next

Letter

Chemical Constituents from Endophytic Fungus Plectosphaerella cucumerina YCTA2Z1 of Cynanchum auriculatum

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    摘要:


    Abstract:
    Objective To study the chemical constituents from the EtOAc extract of endophytic fungal Plectosphaerella cucumerina YCTA2Z1. Methods The chemical constituents were isolated and purified by silica gel column, Sephadex LH-20, and reverse-phase C-18 column chromatography as well as crystallization. Results Thirteen compounds were isolated from the EtOAc extract of the fungal strain YCTA2Z1. Their chemical structures were elucidated according to the spectral evidence. They were identified as caudatin ( 1 ), baishouwubenzophenone ( 2 ), cynandione B ( 3 ), asterbatanoside A ( 4 ), p-hydroxyphenethyl- O - β- D - glycoside ( 5 ), caffeic acid ( 6 ), ferulic acid ( 7 ), 2,5-dihydroxyacetophenone ( 8 ), protocatechuic acid ( 9 ), vanillic acid ( 10 ), stearic acid ( 11 ), azelaic acid ( 12 ), and succinic acid (13). Conclusions It is the first chemical study on endophytic fungi from Cynanchum auriculatum and all the compounds are obtained from the species, the genus, as well as the family Plectosphaerellaceae for the first time.

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    Project Supported:
    National Natural Science Foundation of China ( 21502014 , 274 81673017 , 51408094 ) and Natural Science Foundation of Liaoning 275 Province of China (201602114).

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