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Archive > Volume 10 Issue 2 > 2018,10(2):108-115. DOI:10.1016/j.chmed.2018.02.001 Prev Next

代謝組學(xué)在中藥毒性質(zhì)量標(biāo)志物研究中的應(yīng)用及展望

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Application and Prospect of Toxicity Quality Markers of Traditional Chinese Medicine based on Metabolomics

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    摘要:
    鑒于中藥質(zhì)量評(píng)價(jià)指標(biāo)與中藥有效性及安全性相脫節(jié)的問(wèn)題，劉昌孝院士提出中藥質(zhì)量標(biāo)志物的概念，為完善中藥質(zhì)量控制方法提供一條新的思路。中藥毒性的早期預(yù)測(cè)、中藥毒性質(zhì)量標(biāo)志物的發(fā)現(xiàn)、中藥毒性質(zhì)量標(biāo)志物的形成以及中藥毒性質(zhì)量標(biāo)志物的易感性，這是中藥毒性質(zhì)量標(biāo)志物的幾個(gè)關(guān)鍵環(huán)節(jié)。作為與機(jī)體毒性表型最接近的系統(tǒng)生物學(xué)方法，代謝組學(xué)在中藥毒性質(zhì)量標(biāo)志物研究中具有獨(dú)特的優(yōu)勢(shì)。本文將從四方面進(jìn)行闡釋：1.代謝組學(xué)結(jié)合模式識(shí)別等技術(shù)，建立中藥毒性整體預(yù)測(cè)模型，即代謝組學(xué)在中藥毒性預(yù)測(cè)的應(yīng)用；2.從中藥物質(zhì)成分分析、中藥毒性質(zhì)量標(biāo)志物初篩、中藥毒性質(zhì)量標(biāo)志物驗(yàn)證、毒性機(jī)制的闡釋出發(fā)，闡釋代謝組學(xué)在中藥毒性質(zhì)量標(biāo)志物中發(fā)現(xiàn)中的應(yīng)用；3.從中藥質(zhì)量標(biāo)志物的生源途徑分析、植物次生代謝產(chǎn)物研究出發(fā)，綜述代謝組學(xué)在中藥毒性質(zhì)量標(biāo)志物形成中的應(yīng)用；4.從中藥導(dǎo)致的靶器官毒性易感性出發(fā)，闡釋毒性生物標(biāo)志物的關(guān)鍵靶點(diǎn)及代謝途徑，最終明確“有毒”中藥毒性質(zhì)量標(biāo)志物的易感機(jī)制，即代謝組學(xué)在中藥毒性質(zhì)量標(biāo)志物易感性研究中的應(yīng)用。借助于代謝組學(xué)技術(shù)，有助于系統(tǒng)地、全面地發(fā)現(xiàn)與中藥安全性相關(guān)的質(zhì)量控制指標(biāo)，這為臨床“有毒”中藥的合理應(yīng)用提供有效的保證。

    Abstract:
    In view of the problem that the quality evaluation indicators divorced from effectiveness and safety in Chinese materia medica (CMM), Prof. Chang-xiao Liu et al have put forward a concept of quality markers (Q-markers) of CMM, which provided a new thought for improving the CMM quality control method. The toxicity Q-markers of CMM are described as follows, the early toxicity prediction of CMM, the discovery, formation and susceptibility research of toxicity Q-markers of CMM. Metabolomics is a systematic biology approach, closely related to the toxicity phenotype of organism, has unique advantages in toxicity Q-markers research. The toxicity Q-markers of CMM are explained from the following four aspects in this review: 1) the establishment of toxicity prediction model of CMM, which is based on metabolomics, pattern recognition, and other techniques; 2) the discovery of toxicity Q-markers of CMM based on metabolomic, which is meaning that the toxicity Q-markers are interpreted regarding to the chemical composition analysis of CMM, preliminary screening and verification of the toxicity Q-markers and toxicity mechanism research; 3) the research on the formation of toxicity Q-markers based on metabolomics, which is described from biosynthetic pathway analysis and the secondary metabolites analysis of toxicity Q-markers; and 4) the susceptibility study of toxicity Q-markers based on metabolomics, namely, the key targets, and metabolic pathways of toxicity Q-markers are explained according to the target organ toxicity susceptibility caused by CMM, and then the toxicity susceptibility mechanism of CMM is clarified. Therefore, the application of metabolomics helps to systematically and comprehensively discover the quality control indicators related to the CMM safety, which further provides a rational evidence for the clinical application of toxicity of CMM.

    關(guān)鍵詞:
    代謝組學(xué);毒性質(zhì)量標(biāo)志物;中藥

    Keywords:


    Project Supported:
    This project was supported by the Program for Changjiang Scholars and Innovative Research Team in University (NO. IRT 14R41), the National Natural Science foundation of China (NO. 81573825), the National Natural Science foundation of China (NO. 81273998), and the Research Programs of Application of Basic and Frontier Technology in Tianjin (15JYBJC29400).

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