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Archive > Volume 10 Issue 3 > 2018,10(3):290-297 Prev Next

中藥顆粒劑的水分吸附和擴(kuò)散測(cè)定：糊精為輔料進(jìn)行流化床制粒的防潮效果

Original articles

Moisture sorption and diffusion determination of Chinese Herbal Granules: moisture-resistant effects of fluidized bed granulation with dextrin

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    摘要:
    目的：采用流化床制粒法以糊精為輔料制備了澤瀉湯顆粒，研究其水分吸附和擴(kuò)散特征。方法：采用粒徑、掃描電鏡法（SEM）、差示掃描量熱法（DSC）和傅里葉變換紅外光譜法（FTIR）對(duì)澤瀉湯顆粒進(jìn)行表征，采用飽和鹽溶液法測(cè)定澤瀉湯顆粒的吸濕等溫線、平衡吸濕量、水分?jǐn)U散系數(shù)和擴(kuò)散能量。 結(jié)果：粒徑大小從6.04 μm（澤瀉湯浸膏粉）增加到 1201.47 μm（澤瀉湯顆粒）；糊精、澤瀉湯浸膏粉和澤瀉湯顆粒的玻璃態(tài)轉(zhuǎn)變溫度（Tg）分別為107.13 ℃, 94.82 ℃和126.25 ℃。制粒后，澤瀉湯顆粒的平衡吸濕量和水分?jǐn)U散系數(shù)均顯著降低（p<0.01），臨界相對(duì)濕度和水分?jǐn)U散能量均高于澤瀉湯浸膏粉，能量壁壘的提高阻礙水分在顆粒中的擴(kuò)散。結(jié)論：以糊精為輔料進(jìn)行流化床制粒能夠降低澤瀉湯浸膏粉的吸濕性，抑制水分?jǐn)U散，這可能與流化床制粒改變顆粒的微觀組織結(jié)構(gòu)和糊精的抗塑化作用有關(guān)。

    Abstract:
    Objective To investigate the effects of fluidized bed granulation with dextrin on moisture sorption and diffusion of Zexie Decoction granules. Methods The particle characterization was studied by the particle size, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR). The moisture sorption isotherm, equilibrium moisture content (EMC), and moisture diffusion coefficients were determined by using the saturated salt solution method. Results The particle size increased from 6.04 μm (powder) to 1201.47 μm (granule). The glass transition temperature of dextrin, Zexie Decoction powder, and granule was 107.13 oC, 94.82 oC, and 126.25 oC. As the increase of temperature, the initial rate of moisture sorption become higher. Furthermore, the initial rate of moisture sorption of Zexie Decoction granules was lower than those of powders and dextrin. The EMC and moisture diffusion coefficients were reduced significantly after granulation (p<0.01). Critical relative humidity and diffusion activation energy of granules were higer than powders. Conclusion Results suggested that fluidized bed granulation with dextrin could reduce the hygroscopicity of the Zexie Decoction extract powders and inhibite moisturediffusion, which is mainly related to the microstructure reorganization by fluidized bed granulation and anti-plasticizing effects of dextrin.

    關(guān)鍵詞:
    澤瀉湯顆粒劑;流化床;防潮;擴(kuò)散系數(shù)

    Keywords:


    Project Supported:
    Tianjin Municipal Education Commission Research Project (Grant No. 2017KJ134)

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