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Archive > Volume 10 Issue 3 > 2018,10(3):331-335 Prev Next

桑白皮中α-葡萄糖苷酶抑制和抗氧化活性成分研究

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α-Glucosidase inhibitors and antioxidants from Root Bark of Morus alba

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    摘要:
    目的：研究桑白皮（Morus alba）的化學(xué)成分及其α-葡萄糖苷酶抑制和DPPH自由基清除活性方法：采用硅膠、凝膠柱色譜和制備HPLC等方法進(jìn)行分離純化，通過高分辨質(zhì)譜和核磁鑒定化合物結(jié)構(gòu)結(jié)果：從桑白皮提取物中分離得到了13個(gè)化合物，其中化合物1，3和8表現(xiàn)出顯著的α-葡萄糖苷酶抑制活性，IC50值分別為147.1 ± 1.1，314.1 ± 0.8和207.6 ± 0.1 µM，均低于陽(yáng)性對(duì)照阿卡波糖（418.6 ± 0.1 µM）?；衔?0和11均表現(xiàn)出良好的DPPH自由基清除活性，EC50值分別為2.9 ± 0.1和5.0 ± 0.1 µM，均低于陽(yáng)性對(duì)照維生素C的EC50值（54.8 ± 0.1 µM)結(jié)論：化合物1、3和8的α-葡萄糖苷酶抑制活性為首次測(cè)定。

    Abstract:
    Objective To study the chemical constituents from root bark of Morus alba and their α-glucosidase inhibition and DPPH radical scavenging activities. Methods The chemical constituents were isolated and purified by repeated column chromatographies on silica gel, Sephadex LH-20, and preparative HPLC. Their structures were elucidated by 1D and 2D NMR spectra and HR-ESI-MS. Results Thirteen compounds 1?13 were isolated and identified. The bioactive assays revealed that compounds 1, 3 and 8 displayed strong α-glucosidase inhibitory activity with IC50 values of (147.1 ± 1.1), (314.1 ± 0.8), and (207.6 ± 0.1) μmol/L, respectively, which were stronger than the positive control of acarbose (418.6 ± 0.1 μmol/L). Compounds 10 and 11 displayed potent DPPH scavenging activity with EC50 values of (2.9 ± 0.1) and (5.0 ± 0.1) μmol/L [EC50 of positive control Vitamin C was (54.8 ± 0.1) μmol/L], respectively. Conclusion To the best of our knowledge, this is the first report about the compounds 1, 3 and 8 of M. alba with α-glucosidase inhibitory effects .

    關(guān)鍵詞:
    桑白皮;糖尿病治療;α-葡萄糖苷酶抑制劑;抗氧化劑

    Keywords:


    Project Supported:
    Shaanxi Education Commission (No. 13JS005) and Shaanxi Science and Technology Commission (No. 2014JM2058)

    Clc Number:

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