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Archive > Volume 10 Issue 4 > 2018,10(4):396-404. DOI:10.1016/j.chmed.2018.07.005 Prev Next

多變量建模評(píng)估高剪切制粒工藝對(duì)顆粒產(chǎn)品性能的影響

Original articles

Multivariate modeling to evaluate effect of fabricating process on product profile of high shear granulation

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    摘要:
    目的：為了研究高剪切制粒應(yīng)用于一種可食用中草藥山楂葉的提取物顆粒物的制備過(guò)程的可行性，及進(jìn)一步通過(guò)響應(yīng)曲面、偏最小二乘、多層感知神經(jīng)網(wǎng)絡(luò)探究制粒過(guò)程參數(shù)對(duì)顆粒關(guān)鍵質(zhì)量屬性的影響。方法：采用山楂葉提取物作為制粒的粉體，通過(guò)實(shí)驗(yàn)設(shè)計(jì)方法結(jié)合響應(yīng)曲面、偏最小二乘、多層感知神經(jīng)網(wǎng)絡(luò)考察了高剪切制粒過(guò)程中制粒時(shí)間、葉輪轉(zhuǎn)速和粘合劑用量對(duì)顆粒產(chǎn)物的影響。最后通過(guò)響應(yīng)曲面方法建立了山楂葉提取物在高剪切制粒工藝的設(shè)計(jì)空間。結(jié)果：實(shí)驗(yàn)結(jié)果表明通過(guò)響應(yīng)曲面、偏最小二乘、多層感知神經(jīng)網(wǎng)絡(luò)技術(shù)均能夠增進(jìn)制粒過(guò)程的理解并同時(shí)控制顆粒產(chǎn)物的質(zhì)量。顆粒物的關(guān)鍵質(zhì)量屬性主要受制粒時(shí)間、葉輪轉(zhuǎn)速和粘合劑加入量的影響。響應(yīng)曲面的重疊圖表明在越長(zhǎng)的制粒時(shí)間內(nèi)，葉輪轉(zhuǎn)速和粘合劑加入量所構(gòu)建的設(shè)計(jì)空間的操作范圍最小。結(jié)論：研究表明通過(guò)不同的模型有助于表征高剪切制粒過(guò)程，同時(shí)能夠深入理解制粒行為。

    Abstract:
    Objective: This study aims to investigate the feasibility of high shear granulation (HSG) for agglomeration of Crataegi Folium extract (Chinese edible herbal), and explore the effect of process variables on granule critical quality attributes (CQAs) by three different models, i.e., response surface methodology (RSM), multilayer perceptron neural networks (MLP), and partial least squares method (PLS). Method: RSM, MLP, and PLS complementary to design of experiment (DoE) were utilized to investigate the influence of granulation time, impeller speed, and binder amount on the products. Crataegi Folium extract was employed as granulation powder. RSM was further carried out to develop design space of HSG. Results: The results indicated that RSM, MLP, and PLS modeling techniques enhanced the understanding and controlling of granules produced via HSG. The granule CQAs were mainly influenced by granulation time, impeller speed, and binder amount. Overlay plots of the RSM indicated that design space for the operating ranges of impeller speed and binder amount at high levels of granulation time was the smallest. Conclusion: The study showed that these models were useful to characterize the granulation process, and was particularly important to understand the process.

    關(guān)鍵詞:
    中心復(fù)合設(shè)計(jì);山楂葉;設(shè)計(jì)空間;植物提取物;建模

    Keywords:


    Project Supported:
    Chinese Academy of Sciences (Grant No. 4284135103)

    Clc Number:

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