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Archive > Volume 11 Issue 1 > 2019,11(1):98-102. DOI:10.1016/j.chmed.2018.12.001 Prev Next

蒲黃總黃酮降低高脂血癥大鼠的實(shí)驗(yàn)研究

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Typha angustifolia extract reduces diet-induced hyperlipidemia in rats

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    摘要:
    目的：觀察蒲黃總黃酮降低SD大鼠血脂療效。方法：將60雌雄各半健康大鼠隨機(jī)分為六組，每組10只，空白對照組給予基礎(chǔ)飼料，模型組，6 mg/Kg蒲黃黃酮組，120 mg/Kg蒲黃黃酮組，煙酸組，氟伐他汀組給予60天高脂飲食。隨后120天，6 mg/Kg蒲黃黃酮組、120mg/Kg蒲黃黃酮組、煙酸組、氟伐他汀組給予組大鼠在喂服高脂飼料的基礎(chǔ)上分別予1ml藥物灌胃，第120天采用頸椎脫臼處死大鼠，檢測血TC、LDL、TG、HDL、ET、NO濃度，腹主動脈HE染色，肝臟apoE mRNA及蛋白表達(dá)。結(jié)果：與模型組比較，6 mg/Kg蒲黃黃酮組，120mg/Kg蒲黃黃酮組，煙酸組，氟伐他汀組TC、LDL、TG、HDL、ET、NO降低（P<0.01），肝臟apoE mRNA及蛋白表達(dá)升高（P<0.01），蒲黃黃酮組大鼠腹主動脈無血栓形成。結(jié)論：蒲黃總黃酮有較好的降低血脂和保護(hù)動脈作用。

    Abstract:
    Objective To observe the lipid-lowering effect of Typha angustifolia extract (TAE) in Sprague Dawley rats. Methods The rats were randomly divided into six groups, including the hypercholesterolemic diet (HYD) group. Ad libitum food was given to the animals for 60 d to establish dyslipidemia models. The rats were received an ig administration of 1 mL medicine daily. After 120 d the animals were sacrificed by cervical dislocation; Blood was collected to measure total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), nitric oxide (NO), and endothelin (ET) plasma concentration; Livers were collected to measure ApoE mRNA and protein expression; And morphologic changes of aorta ventralis tissue were observed. Results Compared with HYD group, TAE had the ability of reducing TC, TG, LDL-C, NO, and ET (P < 0.01), thereby increasing ApoE mRNA and protein expression of the liver (P < 0.01). Conclusion These results suggest that TAE is capable of effectively decreasing the circulating lipids levels and enhancing the protective effects of artery.

    關(guān)鍵詞:
    載脂蛋白E;高脂血癥;蒲黃總黃酮

    Keywords:


    Project Supported:
    This work was supported by Research Fund and Natural Science Foundation of Yichang City in Hubei Province, China (No. KFJ2013009; A14301-06).

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