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Archive > Volume 11 Issue 1 > 2019,11(1):113-115 Prev Next

文冠果種仁粕中的一個新香豆素

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A new coumarin glucoside ester from seeds oil leavings of Xanthoceras sorbifolia

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    摘要:
    目的：研究文冠果種仁粕中的香豆素類成分。方法：采用多種柱色譜及制備液相對文冠果種仁粕的香豆素類成分進行分離純化，通過波譜數(shù)據(jù)結(jié)合理化性質(zhì)鑒定了化合物的結(jié)構(gòu)。采用MTT法測定了新化合物對十種人腫瘤細胞株的細胞毒活性。結(jié)果：從文冠果種仁粕中分離得到五個香豆素類化合物分別鑒定為fraxetin-7-O-β-D-[6'-(3''-hydroxyl-3''- methylglutaryl)] glucopyranoside (1)， 秦皮苷 (2)，秦皮素 (3)，東莨菪苷 (4)，秦皮乙素 (5)。結(jié)論：化合物1是未見文獻報道的新化合物。活性測試結(jié)果表明該化合物對十種人腫瘤細胞株均未表現(xiàn)出細胞毒活性。

    Abstract:
    Objective: To study the coumarin from the seeds oil leavings of Xanthoceras Sorbifolia. Methods: The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by spectral and chemical methods. The cytotoxicity of the new compound against ten selected human cancer cell lines was assayed. Results: Five comarins were isolated and identified as fraxetin-7-O-β-D-[6'-(3''-hydroxyl-3''- methylglutaryl)] glucopyranoside (1), fraxoside (2), fraxetin (3), scopoline (4), and esculetin (5), respectively. Conclusion: Compound 1 is a new compound. Unfortunately, this compound exhibited no cytotoxicity with tested cell lines.

    關(guān)鍵詞:
    香豆素;細胞毒活性;秦皮素;秦皮苷;文冠果

    Keywords:


    Project Supported:
    This research was financially supported by the Natural Science Foundation of Liaoning Province (No.2015020720), Teaching Reform Project of Jinzhou Medical University (No.YA2016044) and Student Innovation Training Program of Jinzhou Medical University (No.201710160000082).

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