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Archive > Volume 13 Issue 1 > 2021,13(1). DOI:10.1016/j.chmed.2020.09.002 Prev Next

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Flavonoids in myocardial ischemiaa€“reperfusion injury: Therapeutic effects and mechanisms

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    摘要:


    Abstract:
    Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia–reperfusion injury (MIRI). In this review, we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e) myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.

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    Project Supported:
    We are thankful for financial supports from the National Natural Science Foundation of China (81874336, 81303306); Tianjin Applied Basic and Frontier Technology Research Plan (15JCQNJC13400); The National Natural Science Foundation of Inner Mongolia (2018ZD13).

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