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Archive > Volume 14 Issue 1 > 2022,14(1):5-19. DOI:10.1016/j.chmed.2021.10.008 Prev Next

Reviews

Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer

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    摘要:


    Abstract:
    Chronic atrophic gastritis (CAG), a common disease of digestive system, is an extremely important cause of gastric cancer (GC). The occurrence and development of CAG involves the abnormality of multiple signaling pathways. Traditional Chinese medicines (TCMs) has the advantages of mild action, multi-target and small adverse reaction, etc., which broadens the way for the treatment of the disease, and TCMs can play a therapeutic role by regulating multiple signaling pathways. In this review, based on the related experiments of TCMs and Chinese herbal compounds in recent years, the related literatures were searched and 10 kinds of signaling pathways involved were summarized, in order to provide a reference for further research on reversing or delaying the progress of CAG and preventing gastric cancer.

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    Project Supported:
    The work was supported by the national natural science foundation of China (81673693) and the National Key R&D Program of China (2017YFD0201402) for financial support. The work was also supported by the Scientific Research Innovation Team Foundation of the Logistics University of CPAPF (WHTD2018).

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