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Archive > Volume 14 Issue 1 > 2022,14(1):90-96. DOI:10.1016/j.chmed.2021.10.003 Prev Next

Original articles

Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-?oB signaling

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    摘要:


    Abstract:
    Objective: To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa. Methods: The crude polysaccharide from roots of B. rapa (BRP) was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis. Results: Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity, including increasing production of nitric oxide (NO), tumor necrosis factor α (TNFα) and upregulating mRNA levels of inducible NO synthase (iNOS) and TNFα. Furthermore, modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B (NF-κB). Conclusion: The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases.

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    Project Supported:
    This research was supported by grants from the Natural Science Foundation of China (81760778), the Fundamental Research Funds for Public-interest Scientific Institution in Xinjiang Uygur Autonomous Region (KYGY2016169), and CAMS Innovation Fund for Medical Sciences (2017-I2M-1-012).

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