醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

Archive > Volume 15 Issue 2 > 2023,15(2):201-213. DOI:https://doi.org/10.1016/j.chmed.2022.10.004 Prev Next

合歡抗抑郁的物質(zhì)基礎與作用機理

Reviews

Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae

  • Article
  • Figures
  • Metrics
  • Preview PDF
  • Reference
  • Related
  • Cited by
  • Materials
    摘要:
    合歡是臨床上廣泛使用的抗抑郁藥物。臨床前研究表明，合歡總提取物或其生物活性成分在動物模型中發(fā)揮抗抑郁作用，為揭示合歡潛在的作用機制提供了分子基礎。然而合歡治療抑郁癥的作用機制等許多基本問題在分子和系統(tǒng)水平上仍待解決。在本綜述中，我們通過近期使用抑郁動物模型的臨床前研究及抑郁癥患者的臨床研究，探討和總結(jié)合歡及合歡復方的作用機制。并以幾種具有代表性的生物活性成分和復方作為示例，討論了它們的作用機制。此外，還對在臨床上與傳統(tǒng)抗抑郁藥合并使用的代表性合歡復方進行探討。我們進一步討論了合歡未來的研究方向，以揭示其在分子和系統(tǒng)水平上治療抑郁癥的潛在機制。通過使用分子和系統(tǒng)方法的綜合研究不僅提高對合歡的分子基礎和作用機制的理解，而且為發(fā)現(xiàn)有效和系統(tǒng)地治療抑郁癥的新藥物或新方法提供研究思路。

    Abstract:
    Albizzia julibrissin is empirically used as an antidepressant in clinical practice. Preclinical studies have indicated that its total extracts or bioactive constituents exerted antidepressant-like responses in animal models, providing the molecular basis to reveal its underlying mechanism of action. While attempts have been made to understand the antidepressant effect of A. julibrissin, many fundamental questions regarding its mechanism of action remain to be addressed at the molecular and systems levels. In this review, we conclusively discussed the mechanism of action of A. julibrissin and A. julibrissin formulae by reviewing recent preclinical and clinical studies conducted by using depressive animal models and depressive patients. Several representative bioactive constituents and formulae were highlighted as examples, and their mechanisms of action were discussed. In addition, some representative A. julibrissin formulae that have been shown to be compatible with conventional antidepressants in clinical practice were also reviewed. Furthermore, we discussed the future research directions to reveal the underlying mechanism of A. julibrissin at the molecular and systems levels in depression treatment. The integrated study using both the molecular and systematic approaches is required not only for improving our understanding of its molecular basis and mechanisms of action, but also for providing a way to discover novel agents or approaches for the effective and systematic treatment of depression.

    關鍵詞:
    合歡; 抗抑郁藥; 抑郁癥;作用機制

    Keywords:


    Project Supported:
    This research was funded by the Innovation Research of the Postgraduates of Guangzhou University (2020GDJC-M28); This research was also funded by the Guangdong Basic and Applied Basic Research Foundation (2019A1515011569 and 2021A1515012067) and National Natural Science Foundation of China (32071233).

    Clc Number:

WeChat

Mobile website