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Archive > Volume 15 Issue 2 > 2023,15(2):214-221. DOI:https://doi.org/10.1016/j.chmed.2022.12.007 Prev Next

加味逍遙散治療焦慮癥和焦慮的研究進展

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Jiawei Xiaoyao San in treatment of anxiety disorder and anxiety：A review

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    摘要:
    加味逍遙散在臨床上表現(xiàn)出良好抗焦慮作用，但并未受到廣泛關(guān)注。本文綜述了有關(guān)加味逍遙散抗焦慮作用的動物實驗、臨床研究和作用機制，有望為研發(fā)抗焦慮創(chuàng)新藥物提供參考。所有參考文獻均在PubMed和CNKI數(shù)據(jù)庫中檢索，包括英文文章和含有英文摘要的文章。在臨床研究中，加味逍遙散單用可以緩解患者焦慮癥狀，而與其他藥物聯(lián)用則能減輕藥物不良反應(yīng)。在臨床前研究中，加味逍遙散能夠減輕動物焦慮樣行為。在作用機制研究中，加味逍遙散能夠改善下丘腦-垂體-腎上腺（HPA）軸和相關(guān)激素紊亂，提高神經(jīng)遞質(zhì)含量，增強神經(jīng)發(fā)生，調(diào)節(jié)相關(guān)蛋白酶合成。本文表明加味逍遙散能夠通過調(diào)節(jié)中樞神經(jīng)系統(tǒng)有效治療焦慮癥。未來在更多研究人員參與下，有望基于加味逍遙散開發(fā)抗焦慮創(chuàng)新藥物。

    Abstract:
    Jiawei Xiaoyao San (JWXYS) has shown excellent clinical efficacy in anxiety disorder, but has not yet attracted widespread attention. The animal experiments, clinical trials and mechanism studies of JWXYS were reviewed in this article, which may provide a reference for developing new anxiolytic drugs based on this prescription. The literature was searched in PubMed and CNKI and the documents written in English or with English abstracts were selected. JWXYS could reduce the anxiety symptoms of patients alone and reduce the adverse reactions when it is used in combination with other drugs in the clinic. In preclinical studies, JWXYS also showed therapeutic effects in reducing anxiety-like behavior. The mechanisms may include improving the hypothalamic–pituitaryadrenal (HPA) axis and hormone disorders, increasing neurotransmitter content, neurogenesis, and regulating the synthesis of related enzymes. This article shows that JWXYS could effectively treat anxiety disorders by regulating the central nervous system. In the future, with the participation of more researchers, it is expected to develop innovative drugs for the treatment of anxiety disorders based on JWXYS.

    關(guān)鍵詞:
    抗焦慮作用;焦慮癥;加味逍遙散

    Keywords:


    Project Supported:
    This work was supported by the National Natural Science Foundation of China (No. 81173541).

    Clc Number:

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