醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

Archive > Volume 15 Issue 2 > 2023,15(2):263-270. DOI:https://doi.org/10.1016/j.chmed.2022.09.005 Prev Next

杜仲和補(bǔ)骨脂配伍給藥的藥代動力學(xué)研究

Original articles

Pharmacokinetic study about compatibility of Eucommia ulmoides and Psoralea corylifolia

  • Article
  • Figures
  • Metrics
  • Preview PDF
  • Reference
  • Related
  • Cited by
  • Materials
    摘要:
    目的：杜仲和補(bǔ)骨脂配伍給藥后在大鼠體內(nèi)藥代動力學(xué)屬性的研究。 方法：通過灌胃杜仲提取物、補(bǔ)骨脂提取物或配伍提取物（杜仲提取物、補(bǔ)骨脂提取物生藥比為2:1），開展2個藥代動力學(xué)實驗。實驗一，從大鼠內(nèi)眥眼底靜脈叢取血，獲得目標(biāo)成分的大鼠體內(nèi)的藥代動力學(xué)屬性。實驗二，在不同時間點從頸總靜脈、肝門靜脈同時采集血液樣本，通過LC-MS/MS測定目標(biāo)成分的血藥濃度，以確定杜仲和補(bǔ)骨脂在大鼠體內(nèi)發(fā)生相互作用的部位。 結(jié)果：大鼠血漿中檢測到了杜仲提取物和補(bǔ)骨脂提取物中11個主要成分的8個。配伍給藥后，京尼平苷酸、桃葉珊瑚苷、京尼平苷、松脂醇二葡糖苷、補(bǔ)骨脂苷和異補(bǔ)骨脂苷的暴露水平降低了1/5?2/3。與配伍給藥相比，杜仲提取物單獨(dú)給藥后，門靜脈血樣中的京尼平苷酸和桃葉珊瑚苷的暴露量減少了1/3?-2/3，從肝門靜脈或頸內(nèi)靜脈采集的京尼平苷的AUC0-24h和AUC0-∞增加了1倍，其他藥代動力學(xué)參數(shù)沒有顯著變化。 結(jié)論：總之，杜仲提取物和補(bǔ)骨脂提取物配伍給藥，可能會通過影響腸道吸收而改變杜仲提取物主要成分的暴露水平。杜仲和補(bǔ)骨脂的配伍研究有助于指導(dǎo)杜仲和補(bǔ)骨脂臨床的聯(lián)合用藥。

    Abstract:
    Objective: The compatibility of Eucommia ulmoides (Eu) and Psoralea corylifolia (Pc) on the pharmacokinetic (PK) properties in the rat was explored in this study. Methods: Eu extract, Pc extract and the combined extracts (crude drug ratio was 2:1) was administered by gavage, respectively. Two PK experiments were conducted. In first one, the blood samples were collected via the occuli chorioideae vein to get the PK properties of the components. In second one, the blood samples were simultaneously collected via the internal jugular vein or portal vein at different time points and the concentrations of target ingredients were detected by LC/MS/MS to clear the location where the interaction of Eu and Pc took place in vivo. Results: Eight of 11 ingredients in Eu and Pc extract were determined in rat plasma. The exposure levels of geniposidic acid (GPA), aucubin (AU), geniposide (GP), pinoresinol diglucoside (PDG), psoralen glycosides (PLG) and isopsoralen glycosides (IPLG) were decreased 1/5–2/3 after administration of combined extracts. Comparing to the combined administration, the exposure of GPA and AU in plasma of single Eu administration collected via the portal vein were decreased 1/3–2/3, and the values of AUC0-24h and AUC0-∞ of GP collected from the portal vein or internal jugular vein were double increased. The other components’ parameters were not significantly changed. Conclusion: In summary, the Pc and Eu combined administration could affect the exposure of the main components of Eu extract in rats due to the changed intestinal absorption. The research on the compatibility of Pc and Eu was helpful to guide the clinical administration of Eu and Pc simultaneously

    關(guān)鍵詞:
    雙插管;藥物相互作用;杜仲;液質(zhì)聯(lián)用;藥代動力學(xué)參數(shù);補(bǔ)骨脂

    Keywords:


    Project Supported:
    This study was funded by Key Program for National Natural Science Foundation of China (No. 81630106); National Natural Science Foundation of China (No. 81803691).

    Clc Number:

WeChat

Mobile website