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Archive > Volume 16 Issue 4 > 2024,16(4):548-557. DOI:https://doi.org/10.1016/j.chmed.2024.06.002 Prev Next

原人參二醇型人參皂苷對肝細(xì)胞癌的作用機(jī)制及網(wǎng)絡(luò)藥理學(xué)分析

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Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis

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    摘要:
    肝細(xì)胞癌 （HCC） 是全球最普遍的惡性腫瘤之一，對全球醫(yī)療保健構(gòu)成重大挑戰(zhàn)。原人參二醇型人參皂苷（PDs） 被認(rèn)為可以顯著改善肝臟疾病。PDs，如Rg3，已被開發(fā)為一類新的抗癌藥物。人參皂苷 Rb1、Rd、Rg3 和 Rh2 具有有效的抗炎和抗腫瘤活性。研究證實，PD可用于治療HCC。然而，PDs對HCC的作用機(jī)制尚不清楚。在這項研究中，我們總結(jié)了Rb1、Rd、Rg3、Rg5、Rh2、Rk1和compound K（CK）的抗HCC作用機(jī)制。然后，我們從數(shù)據(jù)庫中檢索PDs和HCC的相關(guān)靶點(diǎn)，并對其進(jìn)行富集分析。隨后，模擬了分子對接，揭示了分子機(jī)制。我們發(fā)現(xiàn)PD可以通過多種信號通路和相關(guān)靶點(diǎn)治療HCC。PDs可以抑制HCC的增殖、侵襲和轉(zhuǎn)移，同時促進(jìn)細(xì)胞凋亡和誘導(dǎo)分化。綜上所述，本文綜述和網(wǎng)絡(luò)藥理學(xué)分析可為相關(guān)機(jī)制的深入研究提供方向。這些見解將有助于進(jìn)一步的藥理學(xué)研究和安全有效的臨床藥物的開發(fā)。

    Abstract:
    Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides (PDs) have been believed to significantly improve liver diseases. PDs, such as Rg3, have been developed as a new class of anti-cancer drugs. Ginsenosides Rb1, Rd, Rg3, and Rh2 exhibit effective anti-inflammatory and anti-tumor activities. Studies have confirmed that PDs could be used to treat HCC. However, the mechanism of action of PDs on HCC remains unclear. In the study, we reviewed the anti-HCC effects and mechanisms of PDs including Rb1, Rd, Rg3, Rg5, Rh2, Rk1, and Compound K (CK). Then, we searched for relevant targets of PDs and HCC from databases and enriched them for analysis. Subsequently, molecular docking was simulated to reveal molecular mechanisms. We found that PDs may treat HCC through multiple signaling pathways and related targets. PDs could inhibit the proliferation, invasion, and metastasis of HCC while promoting apoptosis and inducing differentiation. In conclusion, this review and network pharmacological analysis might offer a direction for in-depth research on related mechanisms. These insights will aid in the direction of further pharmacological studies and the development of safe and effective clinical drugs.

    關(guān)鍵詞:
    抗肝細(xì)胞癌;原人參二醇型人參皂苷;綜述;網(wǎng)絡(luò)藥理學(xué)

    Keywords:


    Project Supported:
    This work was supported by the grants of National Natural Science Foundation of China (No. 82104465), Changchun Science & Technology Development Plan (No. 21ZGY11), and the Scientific Research Planning Project of Jilin Provincial Department of Education (No. JJKH20220371KJ).

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