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Archive > Volume 16 Issue 4 > 2024,16(4):572-588. DOI:https://doi.org/10.1016/j.chmed.2023.09.008 Prev Next

網(wǎng)絡(luò)藥理學(xué)用于闡釋中藥方劑配伍規(guī)律和活性成分的發(fā)現(xiàn)

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Exploration of compatibility rules and discovery of active ingredients in TCM formulas by network pharmacology

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    摘要:
    網(wǎng)絡(luò)藥理學(xué)是通過(guò)使用計(jì)算機(jī)技術(shù)、生物網(wǎng)絡(luò)分析等來(lái)研究中藥方劑中的化合物/有效成分、靶標(biāo)和疾病之間的復(fù)雜關(guān)聯(lián)及相互作用的學(xué)科。中藥方劑由于多成分、多靶標(biāo)、多作用的特性而表現(xiàn)出復(fù)雜性，使得研究它們的物質(zhì)基礎(chǔ)和作用機(jī)制變得具有挑戰(zhàn)性。在傳統(tǒng)中醫(yī)藥學(xué)（TCM）領(lǐng)域，網(wǎng)絡(luò)藥理學(xué)可用于闡明中藥方劑中的配伍關(guān)系和作用機(jī)制，它主要通過(guò)整體識(shí)別中藥方劑中潛在的有效活性成分，預(yù)測(cè)方劑作用的靶標(biāo)，與中醫(yī)藥理論中的整體觀念不謀而合，目前已成為中藥方劑研究中的重要方法之一。本文旨在概述網(wǎng)絡(luò)藥理學(xué)應(yīng)用于中藥方劑配伍規(guī)律方面的研究，并探索其未來(lái)的研究方向。本綜述中，我們重點(diǎn)關(guān)注了網(wǎng)絡(luò)藥理學(xué)在闡釋中藥藥性理論和方劑配伍對(duì)于疾病作用的理解。此外，我們?cè)敿?xì)綜述了網(wǎng)絡(luò)藥理學(xué)鑒定中藥方劑中活性成分的過(guò)程。通過(guò)本綜述的描述，不僅將為網(wǎng)絡(luò)藥理學(xué)與中藥理論整合提供新的研究模型和視角，還提供了網(wǎng)絡(luò)藥理學(xué)中研究中藥方劑配伍的多種新方法?？偟膩?lái)說(shuō)，網(wǎng)絡(luò)藥理學(xué)已成為推動(dòng)中藥方劑研究的一項(xiàng)不可或缺的工具。

    Abstract:
    Network pharmacology is an interdisciplinary field that utilizes computer science, technology, and biological networks to investigate the intricate interplay among compounds/ingredients, targets, and diseases. Within the realm of traditional Chinese medicine (TCM), network pharmacology serves as a scientific approach to elucidate the compatibility relationships and underlying mechanisms of action in TCM formulas. It facilitates the identification of potential active ingredients within these formulas, providing a comprehensive understanding of their holistic and systematic nature, which aligns with the holistic principles inherent in TCM theory. TCM formulas exhibit complexity due to their multicomponent characteristic, involving diverse targets and pathways. Consequently, investigating their material basis and mechanisms becomes challenging. Network pharmacology has emerged as a valuable approach in TCM formula research, leveraging its holistic and systematic advantages. The manuscript aims to provide an overview of the application of network pharmacology in studying TCM formula compatibility rules and explore future research directions. Specifically, we focus on how network pharmacology aids in interpreting TCM pharmacological theories and understanding formula compositions. Additionally, we elucidate the process of utilizing network pharmacology to identify active ingredients within TCM formulas. These findings not only offer novel research models and perspectives for integrating network pharmacology with TCM theory but also present new methodologies for investigating TCM formula compatibility. All in all, network pharmacology has become an indispensable and crucial tool in advancing TCM formula research.

    關(guān)鍵詞:
    活性成分;配伍規(guī)律;分子機(jī)制;網(wǎng)絡(luò)分析;網(wǎng)絡(luò)藥理學(xué);系統(tǒng)生物學(xué);靶點(diǎn)預(yù)測(cè);中醫(yī)藥

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