醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

Archive > Volume 17 Issue 1 > 2025,17(1):31-40. DOI:https://doi.org/10.1016/j.chmed.2024.04.005 Prev Next

基于質譜成像技術的中藥質量標志物發(fā)現與應用

Reviews

Mass spectrometry imaging for unearthing and validating quality markers in traditional Chinese medicines

  • Article
  • Figures
  • Metrics
  • Preview PDF
  • Reference
  • Related
  • Cited by
  • Materials
    摘要:
    中藥質量標志物是中藥質量控制的新概念、新模式，將引領中藥質量發(fā)展新方向。其中，如何表征中藥整體質量屬性及其生物學效應，是質量標志物研究的關鍵科學問題。針對此關鍵科學問題，本文提出基于質譜成像技術（MSI）的研究方法，以發(fā)現和確證中藥質量標志物。MSI是整合了質譜分析和可視化成像分析的新型技術方法，能夠以高空間和高質量分辨率對組織或者細胞中的成分進行可視化。在此基礎上，基于中藥質量標志物確證的五原則，即特異性、有效性、傳遞與溯源、可測性和處方配伍，對候選中藥質量標志物進行確證。

    Abstract:
    Quality marker (Q-Marker) is an innovative concept and model for quality control of Traditional Chinese medicines (TCMs), which will navigate the new direction of quality development of TCMs. Yet, how to characterize the overall quality attributes of TCMs and their biological effects is still debating. In view of this key scientific issue, this paper proposes a research method based on mass spectrometry imaging (MSI) technology for the discovery and confirmation of TCMs Q-Marker. MSI is powerful in investigating the spatial distribution of molecules in a variety of samples, and visualizing the information obtained from MS. On this basis, combine with the five principles of TCMs Q-Marker validation, i.e., specificity, transmission and traceability, testability, prescription compatibility, and validity, were applied to confirm the finalized Q-Marker. It will lead the new direction of quality development of TCMs.

    關鍵詞:
    五原則;質量標志物;質量控制;中藥

    Keywords:


    Project Supported:
    This work was sponsored by the National Natural Science Foundation of China (No. 82303681 & 82202950), the Fundamental Research Funds for the Central Universities (No. 3332022063), and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (No. 2021-I2M-1-042).

    Clc Number:

WeChat

Mobile website