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Archive > Volume 17 Issue 1 > 2025,17(1):41-55. DOI:https://doi.org/10.1016/j.chmed.2024.11.010 Prev Next

植物化學(xué)治療急性髓系白血病的綜合綜述:相關(guān)途徑和分子機(jī)制

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A comprehensive review of phytochemical approaches in treatment of acute myeloid leukemia: Associated pathways and molecular mechanisms

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    摘要:
    急性髓性白血?。ˋML）是一種影響血液和骨髓的癌癥。本綜述對AML進(jìn)行了全面分析，重點(diǎn)探討了其遺傳修飾的特點(diǎn)。此外，還詳細(xì)審視了目前用于AML的治療方法，評估了這些療法的療效及患者在治療過程中經(jīng)歷的顯著副作用，這些因素共同導(dǎo)致了較低的總體生存率。因此，探索替代治療方法（如植物化學(xué)物質(zhì)）顯得尤為重要。 本綜述進(jìn)一步研究了植物化學(xué)物質(zhì)的復(fù)雜領(lǐng)域，并根據(jù)其多樣性將其分類，包括生物堿、酚類、萜類、有機(jī)硫化合物以及包括醌類在內(nèi)的其他化合物，同時(shí)闡明了其作用機(jī)制。特別強(qiáng)調(diào)了這些植物化學(xué)物質(zhì)在關(guān)鍵信號(hào)通路中的作用，尤其是它們在多種細(xì)胞系中對AML的影響。這種深入探索旨在揭示AML分子機(jī)制中的潛在靶點(diǎn)，以發(fā)揮植物化學(xué)物質(zhì)的治療效應(yīng)。 綜述還調(diào)查了植物來源的植物化學(xué)物質(zhì)在AML中作為輔助治療的潛在作用。研究涵蓋了具有顯著抗白血病特性的特定植物化學(xué)物質(zhì)的識(shí)別，并評估了其在臨床環(huán)境中的應(yīng)用潛力。在傳統(tǒng)療法之外，本綜述還探討了將補(bǔ)充與替代醫(yī)學(xué)整合為一種整體性AML管理方法的可能性。研究了傳統(tǒng)療法與替代干預(yù)措施之間的協(xié)同作用，探索這些組合策略如何改善總體治療效果并減輕副作用。 從前瞻性的角度來看，綜述的總體目標(biāo)是通過考慮創(chuàng)新方法，包括單獨(dú)或結(jié)合現(xiàn)有醫(yī)學(xué)干預(yù)的植物化學(xué)物質(zhì)的治療潛力，為AML治療領(lǐng)域的發(fā)展作出貢獻(xiàn)。

    Abstract:
    Acute myeloid leukemia (AML) is a type of cancer that affects the blood and bone marrow. This review conducts a thorough analysis of AML, addressing its genetic modification. The examination extends to the current therapeutic approaches employed for AML, shedding light on their efficacy and the notable side effects experienced by patients undergoing these treatments, leading to a low overall survival rate. Therefore, exploring alternative treatments, such as phytochemicals, is necessary. Furthermore, the review explores the complex landscape of phytochemicals, categorizing them based on their diverse properties, which include alkaloids, phenols, terpenoids, organo-sulfur compounds, and other compounds, including quinones, and elucidating their mechanisms of action. Special emphasis is placed on their involvement in critical signaling pathways, with a particular focus on how these phytochemicals impact AML when evaluated across a spectrum of cell lines. This in-depth exploration aims to uncover potential targets within the molecular landscape of AML where phytochemicals can exert their therapeutic effects. The review investigates the potential role of plant-derived phytochemicals as adjunctive therapies for AML. This exploration encompasses the identification of specific phytochemicals that exhibit promising anti-leukemic properties and evaluates their potential in clinical settings. Beyond conventional treatments, the review explores the integration of complementary and alternative medicine as a holistic approach to managing AML. The examination encompasses the synergy between conventional therapies and alternative interventions, exploring how these combined strategies may enhance overall therapeutic outcomes and mitigate side effects. From a forward-looking perspective, the overarching goal is to contribute to the evolving landscape of AML treatment by considering innovative approaches that harness the therapeutic potential of phytochemicals, both independently and in conjunction with established medical interventions.

    關(guān)鍵詞:
    細(xì)胞死亡;補(bǔ)充與替代醫(yī)學(xué);白血病;植物化學(xué)物質(zhì);信號(hào)通路;治療靶點(diǎn)

    Keywords:


    Project Supported:
    This work was financially supported by the University Grants Commission (UGC), India, through the Senior Research Fellowship (SRF). This support was instrumental in facilitating the comprehensive review of the literature presented in this paper.

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