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Archive > Volume 17 Issue 1 > 2025,17(1):87-93. DOI:https://doi.org/10.1016/j.chmed.2024.03.004 Prev Next

TPMGD：巴基斯坦傳統(tǒng)藥物基因組數(shù)據(jù)庫

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TPMGD: A genomic database for the traditional medicines in Pakistan

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    摘要:
    目的：在巴基斯坦，傳統(tǒng)藥物種類豐富、需求量大，是傳統(tǒng)醫(yī)藥體系中的重要組成部分。但由于傳統(tǒng)藥物資源分散，缺少系統(tǒng)性收集整理，巴基斯坦傳統(tǒng)藥物（TPM）摻假現(xiàn)象普遍存在，嚴(yán)重影響了其用藥安全和藥材的進(jìn)出口貿(mào)易。因此，亟需對TPM進(jìn)行系統(tǒng)性整理與信息化管理，并建立一套標(biāo)準(zhǔn)、可操作的TPM基原鑒定方法。 方法：本研究以巴基斯坦廣泛使用的哈姆達(dá)德藥典第四部分:東方醫(yī)藥的藥典標(biāo)準(zhǔn)為主，搜集和整理了128個TPM的藥用部位，療效和用法，遺傳物質(zhì)等信息。我們從美國國家生物技術(shù)信息中心（NCBI）和全球藥典基因組數(shù)據(jù)庫（GPGD）匯總了TPM的遺傳信息。在此基礎(chǔ)上，采用生物信息學(xué)技術(shù)對12個TPMs的葉綠體全基因組（cp-genome）數(shù)據(jù)進(jìn)行了補(bǔ)充。為了建立web服務(wù)器，我們使用了LAMP系統(tǒng)，并在PHP MVC框架上構(gòu)建了網(wǎng)頁。 結(jié)果：我們構(gòu)建了一個新的基因組數(shù)據(jù)庫，即巴基斯坦傳統(tǒng)藥物基因組數(shù)據(jù)庫。該數(shù)據(jù)庫包括5個條目：網(wǎng)站首頁、物種列表、物種鑒定、“BLAST+”比對工具和下載。目前，該數(shù)據(jù)庫共收錄了128個TPMs的基本簡介和102個TPMs的遺傳信息，其中包括Bombyx mori的140條COI序列和119條線粒體基因組序列、92個植物物種的1 396條ITS2序列和83個植物物種的1 074條psbA-trnH序列。此外，TPMGD還包括82個TPMs的199條葉綠體基因組序列。 結(jié)論：TPMGD是一個集TPM物種描述、功能主治信息查詢、遺傳信息存儲、分子鑒定等多功能為一體的數(shù)據(jù)庫。該數(shù)據(jù)庫不僅為TPM的信息查詢提供了便利，還為TPM的用藥安全、分子鑒定以及資源保護(hù)奠定了科學(xué)基礎(chǔ)。

    Abstract:
    Objective: In Pakistan, traditional medicines are an important component of the medical system, with numerous varieties and great demands. However, due to the scattered resources and the lack of systematic collection and collation, adulteration of traditional Pakistani medicine (TPM) is common, which severely affects the safety of their medicinal use and the import and export trades. Therefore, it is urgent to systematically organize and unify the management of TPM and establish a set of standards and operable methods for the identification of TPM. Methods: We collected and organized the information on 128 TPMs with regard to their medicinal parts, efficacy, usage, and genetic material, based on Pakistan Hamdard Pharmacopoeia of Eastern Medicine: Pharmaceutical Codex. The genetic information of TPM is summarized from national center for biotechnology information (NCBI) and global pharmacopoeia genome database (GPGD). Furthermore, we utilized bioinformatics technology to supplement the chloroplast genome (cp-genome) data of 12 TPMs. To build the web server, we used the Linux + Apache + MySQL + PHP (LAMP) system and constructed the webpage on a PHP: Hypertext Preprocessor (PHP) model view controller (MVC) framework. Results: We constructed a new genomic database, the traditional Pakistani medicine genomic database (TPMGD). This database comprises five entries, namely homepage, medicinal species, species identification, basic local alignment search tool (BLAST), and download. Currently, TPMGD contains basic profiles of 128 TPMs and genetic information of 102 TPMs, including 140 cytochrome c oxidase subunit I (COI) sequences and 119 mitochondrial genome sequences from Bombyx mori, 1 396 internal transcribed spacer 2 (ITS2) sequences and 1 074 intergenic region (psbA-trnH) sequences specific to 92 and 83 plant species, respectively. Additionally, TPMGD includes 199 cp-genome sequences of 82 TPMs. Conclusion: TPMGD is a multifunctional database that integrates species description, functional information inquiry, genetic information storage, molecular identification of TPM, etc. The database not only provides convenience for TPM information queries but also establishes the scientific basis for the medication safety, species identification, and resource protection of TPM.

    關(guān)鍵詞:
    葉綠體基因組;數(shù)據(jù)庫;DNA條形碼;巴基斯坦;傳統(tǒng)藥物

    Keywords:


    Project Supported:
    This study was supported by the Scientific and technological innovation project of the China Academy of Chinese Medical Sciences (No. CI2021A03712, CI2021A03710), the Fundamental Research Funds for the Central Public Welfare Research institutes (No. ZZ15YQ-039), the National Key R&D Program of China (No.2021YFE0100900), and the National Natural Science Foundation of China (No. 82204579). We thank Dr. Baosheng Liao (Second Clinical College, Guangzhou University of Chinese Medicine) for his technical support and database construction.

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