醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

Archive > Volume 17 Issue 1 > 2025,17(1):156-165. DOI:https://doi.org/10.1016/j.chmed.2024.06.001 Prev Next

兩種劑型紫杉醇納米粒瘤內(nèi)注射聯(lián)合光熱治療乳腺癌的研究

Original articles

Intratumoral injection of two dosage forms of paclitaxel nanoparticles combined with photothermal therapy for breast cancer

  • Article
  • Figures
  • Metrics
  • Preview PDF
  • Reference
  • Related
  • Cited by
  • Materials
    摘要:
    目的：將紫杉醇納米粒(PTX NPs)和聚吡咯納米粒(PPy NPs)與光熱治療和化療相結(jié)合，以提高其抗乳腺癌的療效。同時，對PTX納米粒和PTX納米粒凝膠劑兩種劑型進行了比較。方法：采用自組裝法制備PTX納米粒，用四甲基偶氮唑藍(MTT)等方法檢測其體外細胞毒性，并進一步考察其體內(nèi)療效和不良反應(yīng)。結(jié)果：PTX NPs的平均水合直徑為210.20 ± 1.57 nm，平均光密度為0.081 ± 0.003 mV，平均電勢為15.80 ± 0.35 mV。MTT結(jié)果顯示，PTX NPs對4T1細胞的IC50值為0.490 μg/mL，而注射用PTX的IC50值為1.737 μg/mL。PTX NPs的細胞抑制作用約為PTX注射劑的3.5倍。未加近紅外刺激時PTX NPs和凝膠劑的抑瘤率分別為48.64%和56.79%。結(jié)合局部光熱刺激，PTX NPs的抑瘤率達到91.05%，超過相同條件下凝膠劑的抑瘤率(48.98%)，而且PTX NPs的臟器指數(shù)和H&E染色結(jié)果顯示其毒性降低。結(jié)論：該聯(lián)合療法能顯著提高抗乳腺癌的療效，化療與光熱的協(xié)同作用為腫瘤的治療提供了一種可行而有效的策略。

    Abstract:
    Objective: In order to enhance the efficacy of anti-breast cancer, paclitaxel nanoparticles (PTX NPs) and polypyrrole nanoparticles (PPy NPs) were combined with photothermal therapy and chemotherapy. At the same time, the two dosage forms of PTX NPs and PTX NPs gel were compared. Methods: PTX NPs were prepared by self-assembly method, and then the cytotoxicity in vitro was investigated by Methyl thiazolyl tetrazolium (MTT) and other methods, and the efficacy and side effects in vivo were further investigated. Results: The average hydrated diameter, PDI and electric potential of PTX NPs were (210.20 ± 1.57) nm, (0.081 ± 0.003) mV and (15.80 ± 0.35) mV, respectively. MTT results showed that the IC50 value of PTX NPs on 4 T1 cells was 0.490 lg/mL, while that of PTX injection was 1.737 lg/mL. The cell inhibitory effect of PTX NPs was about 3.5 times higher than that of PTX injection. The tumor inhibition rates of PTX NPs and gel were 48.64% and 56.79%, respectively. Together with local photothermal stimulation, the tumor inhibition rate of the PTX NPs reached 91.05%, surpassing that of the gel under the same conditions (48.98%), moreover, the organ index and H&E staining results of PTX NPs showed a decrease in toxicity. Conclusion: This combination therapy can significantly enhance the effect of anti-breast cancer, and the synergistic effect of chemotherapy and light and heat provides a feasible and effective strategy for the treatment of tumor.

    關(guān)鍵詞:
    乳腺癌;聯(lián)合療法;紫杉醇;光熱療法;聚吡咯

    Keywords:


    Project Supported:
    This work was financially supported by CAMS Innovation Fund for Medical Sciences (CIFMS, No. 2021-I2M-1-031, No. 2021-I2M-1-071). The Graphical Abstract was drawn using Figdraw.

    Clc Number:

WeChat

Mobile website