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Archive > Volume 17 Issue 2 > 2025,17(2):203-219. DOI:https://doi.org/10.1016/j.chmed.2024.07.004 Prev Next

基于表觀遺傳調(diào)控的天然產(chǎn)物治療創(chuàng)傷后應(yīng)激障礙的研究進(jìn)展

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Therapeutic potentials of natural products for post-traumatic stress disorder: A focus on epigenetics

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    摘要:
    創(chuàng)傷后應(yīng)激障礙是一種常見(jiàn)且病因復(fù)雜的精神性疾病。典型臨床癥狀包括對(duì)創(chuàng)傷性事件的重新體驗(yàn)或回避、認(rèn)知障礙以及對(duì)周遭事物的高度警惕等。雖然創(chuàng)傷后應(yīng)激障礙的確切發(fā)病機(jī)制尚不清楚，但許多研究表明表觀遺傳調(diào)控在創(chuàng)傷后應(yīng)激障礙發(fā)生及發(fā)展中扮演著關(guān)鍵作用。大量研究表明，創(chuàng)傷后應(yīng)激障礙患者的組蛋白乙?；?甲基化、DNA甲基化和非編碼RNA水平發(fā)生顯著改變。此外，大量研究發(fā)現(xiàn)天然產(chǎn)物可通過(guò)調(diào)節(jié)表觀遺傳修飾酶、長(zhǎng)鏈非編碼RNA和微小RNA的表達(dá)，從而起到改善創(chuàng)傷后應(yīng)激障礙癥狀的作用。當(dāng)前從表觀遺傳角度治療創(chuàng)傷后應(yīng)激障礙的天然產(chǎn)物備受關(guān)注，但尚未有關(guān)于這方面的系統(tǒng)性報(bào)告。所以，本文綜述了天然產(chǎn)物在創(chuàng)傷后應(yīng)激障礙中調(diào)控表觀遺傳調(diào)控的作用和機(jī)制，為創(chuàng)傷后應(yīng)激障礙的治療提供了一個(gè)新穎且獨(dú)特的視角。

    Abstract:
    Post-traumatic stress disorder (PTSD) is a relatively common but complex mental illness with a range of diverse risk factors. Typical symptoms include the re-experience or avoidance of traumatic events, cognitive impairment, and hypervigilance. While the exact pathogenesis of PTSD is unclear, many studies indicate that epigenetic regulation plays a key role in its development. Specifically, numerous studies have indicated that the levels of histone acetylation and methylation, DNA methylation, and noncoding RNA are altered in PTSD patients. Further to this, natural products have been found to achieve epigenetic regulation of PTSD by regulating the expression of epigenetic enzymes, long noncoding RNA (lncRNA), and miRNA, thereby playing a role in improving PTSD symptoms. To date, however, no epigenetic regulation related drugs have been used in the treatment of PTSD. Furthermore, while natural products that can epigenetically regulate PTSD have received increasing levels of attention, there have not yet been any systematic reports on the topic. Here, we summarized the roles and mechanisms of natural products in the epigenetic regulation of PTSD, providing a novel and unique perspective that will help to guide the development and application of new PTSD treatments.

    關(guān)鍵詞:
    DNA甲基化;表觀遺傳調(diào)控;組蛋白修飾;天然產(chǎn)物;非編碼RNA;創(chuàng)傷后應(yīng)激障礙

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    Project Supported:
    This research was supported by the Project of National Natural Science Foundation of China (No. 82074041, 82004051, 81803508), Funded by China Postdoctoral Science Foundation (No. 2020M670674), the Scientific Research Fund from Liaoning Education Department (No. 2020LQN02, LJKZ0923, LJKQZ2021029), Natural Science Foundation of Liaoning Province (No. 2021-MS-216), Fund for distinguished young scholars of Shenyang Pharmaceutical University (No. ZQ202202), Fund for outstanding young scholars of Shenyang Pharmaceutical University (No. YQ202103) and rolling funding of young and middle-aged teachers’ career development project of Shenyang Pharmaceutical University.

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