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Archive > Volume 17 Issue 2 > 2025,17(2):220-234. DOI:https://doi.org/10.1016/j.chmed.2024.09.005 Prev Next

中藥防治輻射損傷的研究進(jìn)展：綜述

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Prevention and treatment of radiation injury by traditional Chinese medicine: A review

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    摘要:
    摘要：核輻射暴露事件和腫瘤放療極易帶來一系列的心理、生理等健康問題，嚴(yán)重影響患者的生活質(zhì)量。研究顯示，放療過程中87.5%的腫瘤患者會出現(xiàn)不同程度的輻射損傷?，F(xiàn)代醫(yī)學(xué)對于輻射損傷的治療局限于藥物治療、細(xì)胞治療等，而且大多化學(xué)藥物會引起許多不良反應(yīng)包括疲憊、惡心、嘔吐等，目前專用于輻射損傷治療的藥物很少。中藥是一種豐富的天然藥用資源，它們具有很廣泛的藥理活性和多種作用靶點(diǎn)，而且毒副作用很小。許多研究表明，中藥或其復(fù)方制劑在治療輻射誘發(fā)的綜合性疾病方面具有巨大潛力。然而，由于中藥起效慢、有效成分復(fù)雜、生物利用度低等原因，其臨床應(yīng)用受到限制。因此，本文在綜述了中藥在抗輻射損傷方面的應(yīng)用與分子機(jī)制及其新劑型研究現(xiàn)狀等基礎(chǔ)上，重點(diǎn)展望了中西醫(yī)結(jié)合手段在中藥防治輻射損傷的開發(fā)優(yōu)勢和應(yīng)用前景。為中藥在臨床有效治療輻射損傷提供科學(xué)有效的給藥策略和基礎(chǔ)理論支持，促進(jìn)中醫(yī)藥的創(chuàng)新發(fā)展。

    Abstract:
    Nuclear radiation exposure events and tumor radiotherapy are highly susceptible to a range of psychological, physiological and other health problems, which can seriously affect patients’ quality of life. It has been shown that 87.5 % of tumor patients are exposed to varying degrees of radiation injury during radiotherapy. The treatment of radiation injury (RI) in modern medicine is limited to drug therapy, cell therapy, etc. Among them, the most chemical drugs cause many adverse reactions including fatigue, nausea, vomiting, etc., and there are very few drugs dedicated to the treatment of RI. Traditional Chinese medicine (TCM) is a rich natural medicinal resource, which has a wide range of pharmacological activities, multiple targets of action and minimal toxic side effects. Many studies have demonstrated that TCM and its compound preparations have enormous potential in the treatment of radiation induced comprehensive diseases. However, TCM is limited in clinical application due to its slow onset of action, complex active ingredients, and low bioavailability. Therefore, the article reviews the application, molecular mechanisms, and new dosage forms of TCM in the prevention and treatment of RI. On this basis, we will focus on discussing the development advantages and application prospects of the combination of traditional Chinese and Western medicine to achieve highly efficient treatment of RI. This review aims to provide scientific and effective drug delivery strategies and basic theoretical support for the clinical effective treatment of RI with TCM, and further promote the innovative development of TCM.

    關(guān)鍵詞:
    中西醫(yī)結(jié)合;新劑型;輻射損傷;中藥

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    Project Supported:
    This work was supported by the Central Guidance on Local Science and Technology Development Fund of Sichucan (No. 2023ZYD0053, China), Central Nervous System Drug Key Laboratory of Sichuan Province (No. 230014-01SZ, China), Special research project of the Sichuan Provincial Administration of TCM (No. 2023MS621, China), the Southwest Minzu University Research Startup Funds (No. RQD2023005, China).

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