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Archive > Volume 17 Issue 2 > 2025,17(2):279-291. DOI:https://doi.org/10.1016/j.chmed.2024.09.001 Prev Next

天然多酚作為衰老和年齡相關(guān)疾病的新的干預(yù)策略：探索其功效、作用機(jī)制及未來(lái)研究的啟示

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Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research

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    摘要:
    天然多酚是廣泛存在于中藥中的一類成分，近年來(lái)，天然多酚已被證明可以延緩或預(yù)防衰老及衰老相關(guān)疾病的發(fā)生。目前，關(guān)于天然多酚在衰老及衰老相關(guān)疾病中的研究尚未得到廣泛綜述。在本文中，我們總結(jié)了近年來(lái)天然多酚在衰老及常見(jiàn)衰老相關(guān)疾病中的研究進(jìn)展以及提高天然多酚生物利用度的現(xiàn)有技術(shù)方法。結(jié)果顯示，天然多酚具有通過(guò)多種機(jī)制預(yù)防或治療衰老及常見(jiàn)衰老相關(guān)疾病的潛力。納米技術(shù)、結(jié)構(gòu)修飾等可為開(kāi)發(fā)預(yù)防或治療衰老及衰老相關(guān)疾病的藥物提供強(qiáng)大的技術(shù)支持?？傊?，天然多酚在衰老及衰老相關(guān)疾病的預(yù)防和治療中具有重要的潛力。

    Abstract:
    Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent years. As far as we know, the studies of natural polyphenols in aging and aging-related diseases have never been extensively reviewed. In the present paper, we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural polyphenols. The results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple mechanisms. Nanotechnology, structural modifications, and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related diseases. In conclusion, natural polyphenols have important potential in the prevention and treatment of aging and agerelated diseases.

    關(guān)鍵詞:
    衰老;癌癥;心血管疾病;天然多酚;神經(jīng)退行性疾病

    Keywords:


    Project Supported:
    This work was supported by National Natural Science Foundation of China (No. 82174076), the Construction Project of Liaoning Provincial Key Laboratory, China (No. 2022JH13/10200026), the Fundamental Research Funds for the Central Universities (No. N2220002) and 111 Project (No. B16009), Natural Science Foundation of Top Talent of SZTU (No. GDRC202404), and Shenzhen Medical Research Fund (No. D2402007).

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