目的 研究炎康顆粒的抗炎作用，并探討其作用機(jī)制。方法 采用巴豆油致小鼠耳腫脹實(shí)驗(yàn)?zāi)Ｐ?、角叉菜膠致雄性大鼠足跖腫脹實(shí)驗(yàn)?zāi)Ｐ?，觀察炎康顆粒對(duì)急性炎癥的作用；采用大鼠棉球肉芽腫實(shí)驗(yàn)?zāi)Ｐ停^察炎康顆粒對(duì)慢性炎癥的作用；采用摘除雙側(cè)腎上腺的大鼠進(jìn)行角叉菜膠致足跖腫脹實(shí)驗(yàn)及棉球肉芽腫實(shí)驗(yàn)，以觀察炎康顆?？寡鬃饔门c下丘腦-垂體-腎上腺軸(HPAA)的關(guān)系。結(jié)果 炎康顆粒8、16 g(生藥)/kg連續(xù)給藥1周，明顯抑制小鼠耳腫脹；4、8 g(生藥)／kg 明顯抑制由角叉菜膠誘導(dǎo)的大鼠足趾腫脹；明顯抑制大鼠棉球肉芽的增生。摘除腎上腺后，炎康顆粒連續(xù)給藥1周，無(wú)明顯抗炎作用。結(jié)論 炎康顆粒對(duì)急性炎癥和慢性炎癥均有明顯的防治作用，其抗炎作用依賴于HPAA系統(tǒng)，并與減少白細(xì)胞介素有關(guān)。

Objective To investigate the antiinflammatory effecet and its mechanism of Yankang Particles.Methods For the sake of observing the effect of Yankang Particles on acute inflammation，the model of mice ear swelling was induced by crotonic oil；the model of rat paw edema was induced by carrageenin. The model of rat cotton pellet granuloma were used to analyse Yankang Particles the effect on chronic inflammation. The models of carrageenin induced paw edema，and cotton pellet granuloma in rat with bilateral adrenalectomized were used to investigate the relationship between the antiinflammatory effect of Yankang Particles and hypothalamuspituitaryadrenal axis (HPAA).Results Yankang Particles 8，16 g (crude drug)／kg can significantly inhibited carrageenininduced rat paw edema after successive administration for 1 week，4, 8 g (crude drug)／kg were capable of inhibit cotton pellet granuloma hyperplasia after successive administration for 1 week．After were adrenalectomized in rats and successive administration for 1 week，there’s no obrviou s antiinflammatory effect.Conclusion The experiments demonstrated the prevention and treatment of Yankang Particles of acute and chronic inflammation, and its antiinflammatory effect dependent on HPAA system，and is associated with decreasing of IL-1β.