目的 觀察腎康顆粒對(duì)慢性腎小球腎炎的治療作用。方法 采用家兔CBSA腎炎、大鼠Heymann腎炎、大鼠高黏滯血癥及大鼠利尿等實(shí)驗(yàn)?zāi)Ｐ?，觀察、測(cè)定相應(yīng)的實(shí)驗(yàn)指標(biāo)。 結(jié)果 腎康顆粒明顯降低24 h尿蛋白的量、血清肌酐及尿素氮水平；抑制腎小球直徑和腎小球細(xì)胞數(shù)的增加；抑制高分子右旋糖酐所致大鼠全血黏度及血漿比黏度的升 高；具有明顯的利尿作用。結(jié)論 腎康顆粒對(duì)動(dòng)物慢性腎炎有明顯的治療作用。

Objective To evaluate the therapeutic effects of Shenkang Particles on chronic glomerulonephritis. Methods C-BSA induced nephritis in rabbits, Heymann nephritis in rats, hyperviscosity in rats, and diuretic test in rats were used to investigate the effect of Shenkang Particles on the experimental indicators. Results Shenkang Particles could significantly decrease urinary protein in 24 h, serum creatinine and blood urea nitrogen, and inhibited the increasing of diameter and cells of glomerulus, increasing of whole blood viscosity and plasma viscosity induced by high molecular dextran. Shenkang Particles showed also diuretic effect significantly.Conclusion Shenkang Particles has obvious therapeutic effect on animals with chronic nephritis.