目的 觀察骨康寧沖劑對(duì)骨質(zhì)疏松的防治作用。方法 采用維甲酸致大鼠骨質(zhì)疏松模型、高分子右旋糖酐致大鼠高黏滯血癥模型以及小鼠鎮(zhèn)痛模型。結(jié)果 與模型對(duì)照組比較，骨康寧明顯升高骨質(zhì)疏松大鼠的骨質(zhì)量、骨密度、骨強(qiáng)度、TBV、血鈣、灰重、骨鈣、骨磷，明顯降低尿鈣；明顯降低高黏滯血癥大鼠的全血黏度；明顯延長(zhǎng)小鼠痛閾、減少扭體次數(shù)。結(jié)論 骨康寧沖劑對(duì)大鼠骨質(zhì)疏松具明顯的防治作用。

Objective To investigate the antiosteoporosis effect of Gukangning granular. Methods Used the rat osteoporosis model induced by vitamin A acid, the rat blood hyperviscosity model induced by dextran, and analgetic model in mice. ResultsCompared with model group, Gukangning granular could increase evidently bone weight, bone mineral density, bone strength, TBV, blood calcium and bone calcium, and bone phosphorus, and decrease urine calcium, blo od viscosity in rats, prolongate threshold of pain, and decrease times of writhing in mice. Conclusion Gukangning granular had remarkably antiosteoporosis effect in rats.