目的 研究芍藥苷的抗抑郁作用，并對其作用機制進地初步探討。方法 采用小鼠強迫游泳、小鼠懸尾實驗和體外培養(yǎng) PC12 細胞的方法，觀察芍藥苷對小鼠游泳不動時間、懸尾不動時間的影響以及對皮質(zhì)酮損傷 PC12 細胞存活率的影響。結(jié)果 芍藥苷連給藥一周后，能明顯縮短小鼠在行為學實驗中的不動狀態(tài)時間，并能拮抗皮質(zhì)酮誘導的神經(jīng)毒作用，提高 PC12 細胞的存活率。結(jié)論 藥苷具有明顯的抗抑郁作用，其機制可能與細胞的保護作用有關(guān)。

Objiective To investigate the antidepressant-like effects and mechanisms of paeoniflorin. Methods The antidepressant effects were evaluated by tail suspension test (TST) and forced swimming tests (FST) in mice. PC12 cells neurotoxicity injury was induced by corticosterone and the cell vialbility were measured by MTT assay. Results The research results indicated that one week of chronic administration paeoniflorin (100,200 mg/kg) could significantly reduce the duration of immobility in both FST and TST. Paeoniflorin at increasing doses （2—10 μmol/L) protected mice against the corticosterone-induced toxicity in PC12 cells in a dose-dependent manner. Conclusion The present study indicates that paeoniflorin has remarkable antidepressant function, which may be related with its cell protection activities.