目的 研究芍藥苷的抗抑郁作用，并對(duì)其作用機(jī)制進(jìn)地初步探討。方法 采用小鼠強(qiáng)迫游泳、小鼠懸尾實(shí)驗(yàn)和體外培養(yǎng) PC12 細(xì)胞的方法，觀察芍藥苷對(duì)小鼠游泳不動(dòng)時(shí)間、懸尾不動(dòng)時(shí)間的影響以及對(duì)皮質(zhì)酮損傷 PC12 細(xì)胞存活率的影響。結(jié)果 芍藥苷連給藥一周后，能明顯縮短小鼠在行為學(xué)實(shí)驗(yàn)中的不動(dòng)狀態(tài)時(shí)間，并能拮抗皮質(zhì)酮誘導(dǎo)的神經(jīng)毒作用，提高 PC12 細(xì)胞的存活率。結(jié)論 藥苷具有明顯的抗抑郁作用，其機(jī)制可能與細(xì)胞的保護(hù)作用有關(guān)。

Objiective To investigate the antidepressant-like effects and mechanisms of paeoniflorin. Methods The antidepressant effects were evaluated by tail suspension test (TST) and forced swimming tests (FST) in mice. PC12 cells neurotoxicity injury was induced by corticosterone and the cell vialbility were measured by MTT assay. Results The research results indicated that one week of chronic administration paeoniflorin (100,200 mg/kg) could significantly reduce the duration of immobility in both FST and TST. Paeoniflorin at increasing doses （2—10 μmol/L) protected mice against the corticosterone-induced toxicity in PC12 cells in a dose-dependent manner. Conclusion The present study indicates that paeoniflorin has remarkable antidepressant function, which may be related with its cell protection activities.