t1/2α)、總消除率(Cl)和藥-時曲線下面積(AUC)等主要藥動學(xué)參數(shù)均有顯著性差異。結(jié)論 在給藥劑量下，單用和合用的血藥濃度變化有較大差異；兩者合用時，地塞米松對綠原酸的藥動學(xué)有顯著影響，促進(jìn)大鼠體內(nèi)綠原酸的消除，從而加速雙黃連的代謝。;Objective To study the concentration and pharmacokinetics parameters of chlorogenic acid in rats after intravenous injection of Shuanghuanglian only or Shuanghuanglian combined with Dexamethasone Sodium Phosphate Injection. Methods A total of 24 SD rats were randomly divided into two groups: single injection group and combination injection group. RP-HPLC method was used to determine the concentrations of chlorogenic acid in rats plasm at different time after intravenous injection of Shuanghuanglian- an only or Shuanghuanglian combined with Dexamethasone. Pharmacokinetic model and parameters were analyzed by Drug and Statistics (DAS 2.0). Results It was two-compartment model in rats. There were significant differences in the main pharmacokinetics parameters such as t1/2α，Cl and AUC between the single injection group and the combination injection group. Conclusion Dexamethasone may change remarkable plasma concentration of chlorgenic acid. There is evidence of pharmacokinetic interaction between Dexamethasone and chlorogenic acid after the intravenous injection in rats. Dexamethasone can enhance the metabolism of Shuanghuanglian."/>

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首頁 > 過刊瀏覽>2010年第25卷第1期 >2010,25(1):45-48. DOI:10.7501/j.issn.1674-5515.[year].1.[sequence]
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地塞米松對注射用雙黃連中綠原酸在大鼠體內(nèi)的藥動學(xué)影響

Effect of dexamethasone on pharmacokinetics of chlorogenic acid in Shuanghuanglian in rats

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    [關(guān)鍵詞]
    [摘要]
    目的 探討與地塞米松磷酸鈉注射液合用時注射用雙黃連中綠原酸在大鼠體內(nèi)血藥濃度及相關(guān)藥動學(xué)參數(shù)的影響。方法 24 只SD系大鼠，雌雄各半，隨機(jī)分成2 組，尾靜脈給藥后采用反相高效液相色譜法，測定單獨(dú)給予注射用雙黃連及與地塞米松合用后不同時間點(diǎn)的大鼠體內(nèi)綠原酸血藥濃度，并對所得數(shù)據(jù)用DAS2.0軟件進(jìn)行分析，求出其主要藥動學(xué)參數(shù)。結(jié)果 靜脈給藥后, 綠原酸在大鼠體內(nèi)符合二室開放模型，在單用和復(fù)合給藥時的分布半衰期(,i>t1/2α)、總消除率(Cl)和藥-時曲線下面積(AUC)等主要藥動學(xué)參數(shù)均有顯著性差異。結(jié)論 在給藥劑量下，單用和合用的血藥濃度變化有較大差異；兩者合用時，地塞米松對綠原酸的藥動學(xué)有顯著影響，促進(jìn)大鼠體內(nèi)綠原酸的消除，從而加速雙黃連的代謝。
    [Key word]
    [Abstract]
    Objective To study the concentration and pharmacokinetics parameters of chlorogenic acid in rats after intravenous injection of Shuanghuanglian only or Shuanghuanglian combined with Dexamethasone Sodium Phosphate Injection. Methods A total of 24 SD rats were randomly divided into two groups: single injection group and combination injection group. RP-HPLC method was used to determine the concentrations of chlorogenic acid in rats plasm at different time after intravenous injection of Shuanghuanglian- an only or Shuanghuanglian combined with Dexamethasone. Pharmacokinetic model and parameters were analyzed by Drug and Statistics (DAS 2.0). Results It was two-compartment model in rats. There were significant differences in the main pharmacokinetics parameters such as t1/2α，Cl and AUC between the single injection group and the combination injection group. Conclusion Dexamethasone may change remarkable plasma concentration of chlorgenic acid. There is evidence of pharmacokinetic interaction between Dexamethasone and chlorogenic acid after the intravenous injection in rats. Dexamethasone can enhance the metabolism of Shuanghuanglian.
    [中圖分類號]
    [基金項(xiàng)目]
    國家自然科學(xué)基金資助項(xiàng)目(20905015)；廣東省自然科學(xué)基金資助項(xiàng)目(9451022401003240)；廣東省科技計(jì)劃資助項(xiàng)目(2008B030301035)；廣東省中醫(yī)藥局資助項(xiàng)目(2009248)