目的 探討新癀片中的中藥組分對化學(xué)藥成分吲哚美辛的減毒作用。方法 采用急性毒性實驗。給ICR小鼠分別ig不同劑量的新癀片、化學(xué)藥成分吲哚美辛，記錄各組小鼠的死亡數(shù)、毒性癥狀，用Bliss法分別計算LD50。同時另設(shè)新癀片中藥組分組，確定其最大給藥量，并觀察毒性反應(yīng)。結(jié)果 新癀片中藥組分對小鼠的1日最大給藥量為18.2 g/kg。吲哚美辛的LD50為18.31 mg/kg，新癀片的LD50為1 217.83 mg/kg，由于吲哚美辛在新癀片中的質(zhì)量分?jǐn)?shù)為2.478%，因此折算成新癀片中吲哚美辛的LD50為30.16 mg/kg。結(jié)論 新癀片中中藥組分對吲哚美辛具有減毒作用。

Objective To study the attenuation effect of Chinese medicinal components in Xinhuang Tablets on indomethacin.Methods Various doses of Xinhuang Tablets and indomethacin were given to ICR mice by ig administrationClinical signs and death were recorded LD50 was computed by Bliss method Meanwhile the maximal administration dose of Chinese medicinal components in Xinhuang Tablets was included，and their acute toxic reactions were observed. Results There were no toxic effects observed when a 18.2 g/kg dose of Chinese medicinal components in Xinhuang Tablets (the maximal acceptable dose) was given to mice. The LD50 of indomethacin in mice was 18.31 mg/kg. The LD50 of Xinhuang Tablets in mice was 1 217.83 mg/kg. As the content of indomethacin in Xinhuang Tablets was 2.478%，the equivalent LD50 of indomethacin in mice was 30.16 mg/kg.Conclusion Chinese medicinal components in Xinhuang Tablets can reduce the toxicity of indomethacin.

國家科技支撐計劃地方重大專項(2007BAQ00162）