摘 要：目的 研究酒石酸美托洛爾脈沖微丸的制備和體外釋放度。方法 采用堿誘導(dǎo)原理制備酒石酸美托洛爾脈沖微丸，考察制備工藝中不同因素對(duì)脈沖微丸體外釋放度的影響。結(jié)果 堿性層增加質(zhì)量不同、遲滯層增加質(zhì)量不同、遲滯層組成不同、增塑劑用量不同和不同粒徑的丸芯均會(huì)影響脈沖微丸的體外釋放。結(jié)論 堿誘導(dǎo)原理制備脈沖微丸的方法操作簡(jiǎn)便，條件可控，制得微丸的脈沖效果理想。

Abstract: Objective To study the preparation of metoprolol tartrate pulsatile pellets and its in vitro dissolution．Methods The metoprolol tartrate pulsatile pellets were prepared by evocation of alkaline layer．The effects of different factors on dissolution in vitro during the preparation of pulsatile pellets were studied．Results The dissolution of metoprolol tartrate pulsatile pellets in vitro was influenced in varying degrees by increased weight of alkaline layer，increased weight and composition of out-layer coating level，dosage of plasticizer，and particle size of pellets．Conclusion The preparation of metoprolol tartrate pulsatile pellets by evocation of alkaline layer is practical and controllable，and the pulse effect of metoprolol tartrate pulsatile pellets is good．

國(guó)家科技支撐計(jì)劃項(xiàng)目子項(xiàng)目（2007BAI41B05）