目的 考察杠柳毒苷在大鼠體內(nèi)的組織分布。方法 采用高效液相色譜法測定大鼠靜脈注射杠柳毒苷后，組織樣品中杠柳毒苷的質(zhì)量濃度。結(jié)果 大鼠iv杠柳毒苷0.74 mg/kg，2、10、20 min后肝中杠柳毒苷的質(zhì)量濃度分別為（2.447± 0.687）、（0.631±0.272）、（0.292±0.228） μg/g，在肝中最高，其次是腎、心、肺、脾和腦。結(jié)論 杠柳毒苷靜脈注射后，在大鼠體內(nèi)分布迅速，主要分布于肝、腎和心中。

Objective To investigate the in vivo tissue distribution of periplocin in rats. Methods An established HPLC-UV method was utilized to determine tissue concentrations of periplocin after iv injection. Results After a single iv dose 0.74 mg/kg to rats, periplocin concentrations in 2, 10, and 20 min was (2.447±0.687), (0.631±0.272), and (0.292±0.228) μg/g in liver, respectively. So the periplocin concentration was maximum in liver followed by kidney, heart, lung, spleen, and brain. Conclusion Periplocin is distributed in rat tissues rapidly following iv injection, and could be mainly distributed in liver, kidney, and heart.

國家自然科學(xué)基金資助項(xiàng)目（30973932）；高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金資助項(xiàng)目（20070063001）