[關(guān)鍵詞]
[摘要]
枇杷花具有重要的藥用價(jià)值和開發(fā)潛力。近年來國內(nèi)外相關(guān)研究主要集中在枇杷花的化學(xué)成分、提取和精制工藝、藥理效應(yīng)和應(yīng)用開發(fā)等方面,但存在有效性評價(jià)方法不系統(tǒng)和有效劑量不明確等問題。在綜述枇杷花化學(xué)成分、提取和精制工藝、藥理作用的基礎(chǔ)上,提出如下研究思路:基于傳統(tǒng)用藥經(jīng)驗(yàn),應(yīng)用經(jīng)典、快速的動(dòng)物模型確定有效劑量范圍,整合多致病因素、多模型動(dòng)物和多藥理效應(yīng)的藥效學(xué)評價(jià)體系,引入模式識別分析等統(tǒng)計(jì)學(xué)方法,綜合評價(jià)枇杷花的鎮(zhèn)咳有效性并研究其作用機(jī)制,以期為枇杷花的開發(fā)提供科學(xué)依據(jù)。
[Key word]
[Abstract]
Loquat flower (the flower of Eriobotrya japonica) possesses important medicinal application value and great potential for development. In recent years, the related studies about loquat flower have been focused on chemical composition, techniques of extraction and purification, pharmacological effects, and application development. Nevertheless, research problems are still existed. For example, the methods of the efficacy evaluation are not systemic and the effective dose is not definite. This paper puts forward some research ideas as following. Based on the experience of traditional medicine, the effective dose could be defined through some classical and rapid animal models. Meanwhile, by using the pharmacological evaluation system which integrates the multi causative factors, multi animal models, multi pharmacological effects, and the pattern recognition technology, the antitussive effect of loquat flower could be synthetically estimated, its mechanism of action studied, and scientific proofs to exploit loquat flower provided as the new part-used for medicine materials.
[中圖分類號]
[基金項(xiàng)目]