目的 建立清咽滴丸中沒食子酸溶出度的測定方法。方法 采用高效液相色譜法對沒食子酸進行測定，遴選溶出條件，計算并繪制出沒食子酸累積溶出曲線。采用槳法，轉(zhuǎn)速100 r/min，以蒸餾水為溶出介質(zhì)。結(jié)果 沒食子酸在0.01～0.20 μg線性關(guān)系良好（r=0.999 9），樣品回收率為100.50%，RSD為1.60%。結(jié)論 本方法靈敏準確，專屬性強，為該制劑的質(zhì)量控制提供了良好保證。

Objective To establish a method of dissolution determination of gallic acid in Qingyan Dropping Pills. Methods The content of gallic acid was determined by HPLC. The determination conditions of dissolution were selected, results were calculated, and cumulative dissolution curves were drawn. By slurry method, distilled water was taken as dissolution medium, at speed of 100 r/min. Results The linear range was of 0.01—0.20 μg for gallic acid and the correlation coefficient was 0.999 9. The average recovery was 100.50% with RSD 1.60%. Conclusion: The method is simple, accurate, and could provide good guarantee for the quality control of the preparation.

天津市高等學?？萍及l(fā)展基金計劃項目（20060302）