甘草及其活性成分能提高吞噬細(xì)胞的吞噬功能、調(diào)節(jié)淋巴細(xì)胞數(shù)量與功能、抑制IgE抗體形成、抗炎癥介質(zhì)及前炎性細(xì)胞因子，具有抗炎、抗變態(tài)反應(yīng)的藥理活性。甘草黃酮類化合物（異甘草素、異甘草苷、甘草素、甘草查耳酮A、光甘草定、甘草醇等）、甘草多糖和甘草酸是其抗炎、抗變應(yīng)性炎癥的活性成分。其中對(duì)異甘草素、甘草查耳酮A和甘草酸的抗炎及抗變應(yīng)性炎癥作用的研究較為深入。綜述甘草及其活性成分的抗炎作用及抗炎機(jī)制的研究進(jìn)展。

Glycyrrhizae Radix et Rhizoma and its active components can enhance the phagocytic function of phagocytes, modulate the quantity and function of lymphocytes, inhibit the antibody formation of IgE, possess the effects against inflammatory mediator and proinflammatory cytokines, and induce pharmacologic activities against inflammation and allergy. Flavonoids (isoliquiritigenin, isoliquiritin, liquiritigenin, licochalcone A, glabridin, glycyrol, and so on), glycyrrhiza polysaccharide and glycyrrhizic acid are active components of Glycyrrhizae Radix et Rhizoma on anti-inflammation and immunoregulation. Among others, the anti-inflammation and anti-allergy of isoliquiritigenin, licochalcone A and glycyyrrhizic acid are studied more profoundly. Research advances on the anti-inflammation and mechanism of Glycyrrhizae Radix et Rhizoma and its active components are reviewed in this paper.