長(zhǎng)春花屬植物是原產(chǎn)于非洲東海岸的野生花卉，現(xiàn)已廣泛分布于世界各地。長(zhǎng)春花含有萜類生物堿、二聚吲哚生物堿、單吲哚生物堿等多種生物堿類活性成分和黃酮類成分。近年來長(zhǎng)春花中單體成分或結(jié)構(gòu)修飾物作為藥物被廣泛用于治療多種癌癥、糖尿病、高血壓及何杰金氏病。綜述了近年來對(duì)長(zhǎng)春花生物堿類和藥理活性的研究進(jìn)展，為更好地開發(fā)、利用長(zhǎng)春花提供參考。

Plants of Catharanthus G.. Don genus are wild flowers which originate from east coast of Africa, and widely distribute all over the world now. There are many kinds of active alkaloids and flavanoid in catharanthus roseus, including terpenoid alkaloid, indole alkaloid dimmers, and indole alkaloid, etc. In recent years, monomer composition or structural modification drugs of Catharanthus plants have been widely used to treat many kinds of cancers, diabetes, and Hodgkin's disease. Since each constituent has much bioactive,the paper summarize research advance in recent years on alkloid composition and pharmacological activity.