目的 探討壽胎丸對(duì)腎虛–黃體抑制流產(chǎn)模型（病證結(jié)合模型）大鼠雌激素水平的影響。方法 應(yīng)用羥基脲和米非司酮制備SD大鼠腎虛–黃體抑制流產(chǎn)模型。給模型大鼠壽胎丸進(jìn)行干預(yù)，肉眼觀察子宮病變，記錄胚胎數(shù)，計(jì)算流產(chǎn)率；化學(xué)發(fā)光法檢測(cè)血清雌二醇（E2）、孕酮（P）的水平。結(jié)果 壽胎丸能明顯降低大鼠的流產(chǎn)率，增加胚胎數(shù)，提高血清E2和P水平。結(jié)論 壽胎丸對(duì)腎虛–黃體抑制流產(chǎn)模型大鼠具有良好的保胎作用，其通過提高雌激素水平、增強(qiáng)黃體功能，維持妊娠，發(fā)揮補(bǔ)腎安胎的作用。

Objective To explore the effect of Shoutai Pills on the estrogen level of abortion model SD rats suffered from corpus luteum inhibition due to kidney deficiency (disease-syndrome combination model). Methods Applying hydroxycarbamide and mifepristone to establish the abortion model with corpus luteum inhibition due to kidney deficiency of SD rats. Using Shoutai Pills formula to treat the model rats, observing the uterus condition, and recording the embryo numbers and the miscarriage rate of each rat. The serum estradiol (E2) and progesterone (P) levels of these two groups were determined by chemoluminescence. Results Compared with the model group, the abortion rate was greatly reduced and the embryo number and the serum E2 and P levels were obviously increased in the treating group. Conclusion Shoutai Pills can apparently improve the condition of this disease-syndrome combination model. It can improve the condition of the model rats through elevating the E2 and P levels and reinforce the corpus luteum function to maintain the pregnancy, so it can achieve the effects of tonifying the kidney and preventing abortion.