目的 研究復(fù)方風(fēng)濕寧注射液的抗炎作用。方法 采用大鼠角叉菜膠致關(guān)節(jié)炎模型、大鼠佐劑性關(guān)節(jié)炎模型和大鼠棉球肉芽腫模型，觀察復(fù)方風(fēng)濕寧注射液的抗炎、消腫作用，并測定角叉菜膠誘發(fā)的關(guān)節(jié)炎模型大鼠致炎足炎癥滲出液中前列腺素E2（PGE2）的水平。結(jié)果 與模型組比較，復(fù)方風(fēng)濕寧注射液顯著減輕角叉菜膠所致踝關(guān)節(jié)炎癥大鼠的足腫脹度（P＜0.05、0.01），顯著減少大鼠致炎足炎癥滲出液中PGE2的水平（P＜0.01）；顯著抑制佐劑性關(guān)節(jié)炎模型大鼠足跖腫脹度（P＜0.05、0.01），顯著減輕大鼠棉球肉芽腫的干質(zhì)量（P＜0.05）。結(jié)論 復(fù)方風(fēng)濕寧注射液具有抗炎作用，其機(jī)制可能與抑制PGE2合成與釋放有關(guān)。

Objective To study the anti-inflammatory effect of Compound Fengshining Injection. Method The anti-inflammatory effect of the injection was assessed by carrageenan-induced arthritis rats, adjuvant-induced arthritis rats, and cotton ball granuloma rats. Content of prostaglandin E2 (PGE2) in inflammatory exudate of the carrageenan-injected paw was detected. Result Compared with model group, Compound Fengshining Injection significantly decreased the ankle swelling degree of carrageenan-induced arthritis rats (P＜0.05, 0.01) and reduced the content of PGE2 in the inflammatory exudate of carrageenan-injected paws (P＜0.01). Compared with the model group, Compound Fengshining Injection remarkably inhibited the joint swelling of adjuvant-induced arthritis rats (P＜0.01, 0.05). Compared with the control group, Compound Fengshining Injection remarkably lightened the granulomatous weight of cotton ball granuloma rats (P＜0.05). Conclusion Compound Fengshining Injection has a determinate anti-inflammatory effect and the effect possibly related to the inhibiting of synthesis and release of PGE2.