目的 制定沈陽紅藥氣霧劑的質(zhì)量控制標(biāo)準(zhǔn)。方法 采用薄層色譜法對制劑中的三七、當(dāng)歸、川芎、白芷、冰片、薄荷腦進行定性鑒別，采用高效液相色譜法測定制劑中人參皂苷Rg1。色譜柱為Diamonsil C18柱（200 mm×4.6 mm，5 μm）；流動相為乙腈–0.5%磷酸水溶液（20∶80）；體積流量為1.0 mL/min；檢測波長203 nm。結(jié)果 三七、當(dāng)歸、川芎、白芷、冰片、薄荷腦薄層色譜斑點清晰，重現(xiàn)性好，無干擾；人參皂苷Rg1在0.05～0.50 mg線性關(guān)系良好，平均回收率為100.6%，RSD為1.07%（n=6）。結(jié)論 所建立的定性和定量方法結(jié)果準(zhǔn)確、可靠、重現(xiàn)性好，可用于沈陽紅藥氣霧劑的質(zhì)量控制。

Objective To establish the quality standard of Shenyang Hongyao Aerosol. Methods TLC was applied to identifying Notoginseng Radix et Rhizoma, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Angelicae Dahuricae Radix, Borneolum Syntheticum, and Menthae Haplocalycis Herba. HPLC was applied to determining the content of ginsenoside Rg1 in the prescription. Diamonsil C18 column (200 mm×4.6 mm, 5 μm) was used, the mobile phase consisted of acetonitrile-0.5% phosphoric acid (20:80) solution, and the flow rate was 1.0 mL/min with detection wavelength at 203 nm. Results The spots on TLC plates of above mentioned six material medica were clear with good reproducibility and without interference in the blank reference. The linearity range of ginsenoside Rg1 was 0.05—0.50 mg, the average recovery rate was 100.6%, and RSD was 1.07% (n=6). Conclusion The established method is accurate, feasible, and reproducible. It can be used for the quality control for Shenyang Hongyao Aerosol.