目的 建立抗感泡騰片提取液中酚酸類成分的測定方法，為抗感泡騰片生產(chǎn)過程的在線質(zhì)量控制提供參考。方法 以抗感泡騰片生產(chǎn)工藝為基礎(chǔ)，在線收集樣品。通過亞硝酸鈉顯色反應(yīng)，采用分光光度法以綠原酸為對照品對樣品進(jìn)行分析。結(jié)果 綠原酸在0.083～0.332 mg呈線性關(guān)系，平均回收率為101.91%，RSD為1.65%。結(jié)論 該方法有利于生產(chǎn)過程中的質(zhì)量控制，且簡便、準(zhǔn)確、可靠，可作為抗感泡騰片的質(zhì)量控制方法。

Objective To establish a method for the determination of phenolic acids in extract solution of Kanggan Effervescent Tablet, and provide reference for Kanggan Effervescent Tablet quality control of the production process. Method Based on the production process of Kanggan Effervescent Tablet, collection of samples was online carried out. The chlorogenic acid were determined with the chlorogenic acid as a control standard by spectrophotometry through the color reaction of sodium nitrite. Results Good linearity of chlorogenic acid was obtained within the range of 0.083—0.332 mg . The recovery was 101.91%, and RSD was 1.65%. Conclusion The method is simple, accurate , reliable, and conducive to the quality control in the production process, and it can be used as a method for Kanggan Effervescent Tablet quality.

北京市科技計劃項目（D0205004040331）