使骨吸收增加或骨形成減少的因素都會誘導(dǎo)骨質(zhì)疏松癥的發(fā)生。脂聯(lián)素作為近年來發(fā)現(xiàn)的一種內(nèi)源性的生物活性多肽類物質(zhì)，除觀察到對糖脂代謝、血管內(nèi)皮及平滑肌功能、腫瘤壞死因子等方面有作用外，在骨代謝中亦發(fā)揮重要作用，可直接或間接地影響骨吸收和骨形成這兩大骨代謝方面。脂聯(lián)素在骨組織中的生理作用的實質(zhì)是對成骨和破骨兩方面綜合影響的結(jié)果。

At present, the factors which could increase bone absorption or inhitit osteogensis may induce the occurrence of osteoporosis disease. As an endogenous bioactive peptides discovered in recent years, adiponectin has the effect on glycolipid metabolism, function of vascular endothelial and smooth muscle, and tumor necrosis factor. Beyond these, adiponection also plays an important role in bone metabolism that could affect the bone absorption and osteogensis directly or indirectly. As a matter of fact, the action of adiponectin in physiological effect of bone tissue is a comprehensive influence on osteogenesis and broken bone essentially.