通關(guān)藤含有三萜、甾醇、有機(jī)酸等化學(xué)成分，其活性成分主要為研究較多的C21甾體類化合物，而對(duì)其他成分的研究較少；現(xiàn)代藥理研究表明，其具有較強(qiáng)的生物活性，在抗腫瘤、降壓、平喘等方面有著顯著作用。通關(guān)藤經(jīng)提取制成的一系列藥物制劑在臨床上已得到廣泛應(yīng)用，其中消癌平注射液治療癌癥療效較好。對(duì)近年來通關(guān)藤及其制劑的藥理研究和臨床應(yīng)用進(jìn)行概述，為其進(jìn)一步研究、開發(fā)和臨床合理用藥提供參考。

Marsdenia tenacissima is a Chinese medicine with antitumor effect, and its chemical compositions include triterpenoids, sterols, organic acids, and so on. The main antitumor active compositions of C21 steroids have been studied more than others. Modern pharmacological studies have shown the strong biological activity and the significant role on the antitumor, blood pressure, asthma and so on. Nowadays M. tenacissima and its preparation have extensive application in clinic. In this paper, pharmacological effects and clinical applications of M. tenacissima and its preparations had been reviewed to provide the theoretical basis for its further research.

江蘇省中醫(yī)藥領(lǐng)軍人才項(xiàng)目（LJ200906）；江蘇省高校優(yōu)勢(shì)學(xué)科建設(shè)工程資助項(xiàng)目