目的 觀察過山蕨總黃酮對(duì)血栓閉塞性脈管炎模型大鼠的改善作用。方法 大鼠股動(dòng)脈注射月桂酸制備血栓閉塞性脈管炎，造模后肉眼觀察病變肢情況并評(píng)分，按評(píng)分結(jié)果將大鼠隨機(jī)分為模型組，對(duì)照組，過山蕨總黃酮高、中、低劑量（7.2、3.6、1.8 mg/kg）組和脈管復(fù)康片（648 mg/kg）陽(yáng)性對(duì)照組，每組10只，給藥組于造模3 d后每天ig給藥1次，連續(xù)7 d。觀察大鼠體征、血栓病理切片、血液流變學(xué)指標(biāo)。結(jié)果 過山蕨7.2 mg/kg可顯著改善血栓性閉塞性脈管炎模型大鼠的癥狀。

Objective To observe the improving effect of total flavonoids from Camptosorus sibiricus on rats with thromboangiitis obliterans. Methods The thromboangiitis obliterans of rats was made by administration lauric acid into femoral artery. After the models were made, the limb lesions were observed and scored, by which the rats were divided into model group, control group, administration group (7.2, 3.6, and 1.8 mg/kg), and Maiguan Fukang Tablet (648 mg/kg) as positive control group with ten in each group, respectively. After the models were made for 3 d, the successive ig administration was given once a day for 7 d. The physical signs, pathological sections, and hemorheological indexes were investigated. Results The significant improving effect of total flavonoids from C. sibiricus on model rats with thromboangiitis obliterans was observed in the high dose (7.2g/kg) group. Conclusion The treatment of the total flavonoids from C. sibiricus on rats with thromboangiitis obliterans may be related to the effect of blocking α-receptor, exciting β-receptor, antinorepinephrine, and inhibiting the platelet aggregation induced by ADP.

“重大新藥創(chuàng)制”科技重大專項(xiàng)（2009ZX09102）；遼寧省博士科研啟動(dòng)基金資助項(xiàng)目（20091079）