心腦血管疾病嚴重威脅人類健康，抗血小板治療已經(jīng)被證明可以有效預(yù)防和改善心腦血管疾病。噻吩并吡啶類藥物是以二磷酸腺苷受體為靶點的一類抗血小板藥物，包括噻氯匹定、氯吡格雷和普拉格雷，是目前臨床上應(yīng)用最為廣泛、有效的抗血小板聚集、抗血栓藥物，極大地改善了全球心腦血管患者的健康狀況。概括介紹噻吩并吡啶類藥物的代謝與起效模式、作用機制、臨床應(yīng)用及藥物相互作用等方面的研究進展。

Cardiovascular and cerebrovascular diseases have become the number one killer which could cause death. Antiplatelet therapy has been shown to be effective to do some prevention and improvement. Thienopyridines, including ticlopidine, clopidogrel, and prasugrel, which are a class of drugs targeting at ADP receptor, have been widely used in clinical practice to greatly improve the health of cardiovascular and cerebrovascular diseases status around the world. The objective of this article is to summarize the research progress in drug metabolism, mode of actions, clinical practice, and the drug-drug interactions of thienopyridines in brief.

國家重大新藥創(chuàng)制專項（2011ZX09401-009）