目的 觀察生脈丹咀嚼片對高脂模型大鼠血脂及血液流變學的影響。方法 ig給予大鼠高脂乳劑，形成高脂模型，同時ig給予0.5、1.0、2.0 g生藥/kg的生脈丹咀嚼片，4周后檢測血液中總膽固醇（TG）、三酰甘油（TC）、低密度脂蛋白膽固醇（LDL-C）、高密度脂蛋白膽固醇（HDL-C）水平及血黏度、血漿黏度、紅細胞壓積、紅細胞聚集指數(shù)、紅細胞變形指數(shù)等血流變學指標。結果 生脈丹咀嚼片各劑量組均可以降低模型大鼠血清TC和LDL-C水平，其中2.0 g生藥/kg組與模型組比較具有統(tǒng)計學意義（P＜0.01）。生脈丹咀嚼片0.5 g生藥/kg組還具有一定的降低模型大鼠血清TG的作用（P＜0.01）；同時生脈丹咀嚼片各給藥組可以降低高血脂模型大鼠全血低切還原黏度、血漿黏度、紅細胞壓積及紅細胞聚集指數(shù)（P＜0.01），對紅細胞變形指數(shù)無明顯影響。結論 生脈丹咀嚼片具有一定的降低高脂模型大鼠的血脂和改善血流變學的作用。

Objective To observe the effects of Shengmaidan Chewable Tablets on blood lipid and hemorheology in hyperlipedemic model rats. Methods Hyperlipedemic models were established by ig administration with high fat emulsion, meanwhile the Shengmaidan Chewable Tablets were given in three dosages 0.5, 1.0, and 2.0 g/kg. The blood levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected after four weeks. Whole blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index, and index of erythrocyte deformability were determined at the same time. Results Shengmaidan Chewable Tablets could reduce the blood levels of TC and LDL-C. Compared with the model group, Shengmaidan Chewable Tablets high dosage (2.0 g/kg) group could reduce TC and LDL-C in rat serum obviously (P<0.01), low dosage (1.0 g/kg) group could reduce TG in rat serum obviously (P<0.01). Shengmaidan Chewable tablets could notably decrease low-shear reduced viscosity of whole blood, plasma viscosity, hematocrit, and erythrocyte aggregation index (P<0.01), while had no obvious effect on the index of erythrocyte deformability. Conclusion Shengmaidan Chewable Tablets shows clear improvement for the serum level of lipidemic and hemorrheologic exception in hyperlipedemic rats.

科技部重大新藥創(chuàng)制項目（2011ZX09401-014）