目的 檢測使用三氧化二砷（As2O3）治療急性早幼粒細(xì)胞性白血?。ˋPL）后患者骨髓和血液中砷的濃度，分析砷暴露及暴露時(shí)間對(duì)機(jī)體的影響。方法 對(duì)30名砷暴露患者及28名非砷暴露患者進(jìn)行調(diào)查，對(duì)30名暴露者，其中包括砷暴露1年半以上（13人）、一年半以內(nèi)（17人）以及未暴露組進(jìn)行調(diào)查研究；同時(shí)隨機(jī)抽取7名暴露者，采用氫化物發(fā)生原子吸收分光光度法檢測骨髓和血液中砷代謝產(chǎn)物，對(duì)其骨髓和血液中砷濃度進(jìn)行對(duì)比。結(jié)果 7例暴露組患者的骨髓與血液中砷濃度對(duì)比，骨髓砷濃度（7.99±0.15）μg/L；血液中的砷濃度（7.98±0.15）μg/L，差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）；同時(shí)對(duì)暴露一年半以上，暴露一年半以內(nèi)及對(duì)照組進(jìn)行單因素分析t檢驗(yàn)的方法，其兩兩之間進(jìn)行比較發(fā)現(xiàn)暴露一年半以上組與暴露一年半以內(nèi)組差異有統(tǒng)計(jì)學(xué)意義（P＜0.05），兩個(gè)暴露組與對(duì)照組比較，差異均有統(tǒng)計(jì)學(xué)意義（P＜0.05）。結(jié)論 As2O3治療ALP，砷可以到達(dá)骨髓并進(jìn)行緩慢代謝，且在骨髓中的代謝與在血液中基本相同，隨著暴露時(shí)間間隔的延長砷濃度有下降趨勢。

Objective To detecte arsenic concentration in the bone marrow and blood after As2O3 used for in the treatment of acute promyelocytic leukemia (APL), and to analyze the effects of arsenic exposure and exposure time on the body. Methods Thirty arsenic exposed patients including arsenic exposure (13) more than a year and a half and those within a year and a half (17) and 28 non-arsenic exposed patients were investigated, investigated 30 exposed persons. Meanwhile, 28 patients with bone marrow and blood arsenic concentration were compared. Seven exposed patients were randomly selected to compare arsenic concentration in the bone marrow and blood by hydride generation atomic absorption spectrophotometry in the detection of bone marrow arsenic metabolites. Results The arsenic concentration of bone marrow was (7.99 ± 0.15)μg/L and that of the blood was (7.98 ± 0.15)μg/L, with no significant difference (P>0.05). At the same time, patients exposed to more than a year and a half, exposure to less than a year and a half, and the control group were compared between any two by univariate analysis, t test method, and the results showed that difference between any two groups were statistically significant (P<0.05). Conclusion When As2O3 are used for APL, arsenic could reach the bone marrow and to slow metabolism; Arsenic metabolisms in the bone marrow and in blood metabolism are basically the same, with the extension of exposure time interval the concentration of arsenic shows a downward trend.