目的 對(duì)膠南市人民醫(yī)院ICU 97例銅綠假單胞菌感染的分布及耐藥性進(jìn)行分析，為臨床合理用藥提供依據(jù)。方法 通過(guò)分析2009年1月—2010年12月ICU發(fā)生的97例銅綠假單胞菌感染的臨床觀察資料，評(píng)估感染高危因素；以Kirby-Bauer紙片擴(kuò)散法藥敏實(shí)驗(yàn)監(jiān)測(cè)銅綠假單胞菌的抗藥性。結(jié)果 膠南市人民醫(yī)院ICU發(fā)生的97例銅綠假單胞菌醫(yī)院感染以下呼吸道感染最為常見(jiàn)，銅綠假單胞菌對(duì)抗菌藥物具有多重耐藥性，以碳青霉烯類-亞胺培南的抗菌活性最好。結(jié)論 ICU內(nèi)應(yīng)嚴(yán)格執(zhí)行消毒隔離制度和無(wú)菌操作，盡量避免銅綠假單胞菌感染的發(fā)生；臨床用藥時(shí)應(yīng)合理使用抗生素，盡可能減少細(xì)菌耐藥性的產(chǎn)生。

Objective To analyze the Pseudomonas aeruginosa (Schroeter) Migula distribution and drug resistance in 97 cases in ICU of People’s Hospital of Jiaonan which could provide certain reference for using the drugs reasonably. Methods The clinical data of the 97 cases with Pseudomonas aeruginosa (Schroeter) Migula infection in ICU from January, 2009 to December, 2010 were reviewed to evaluate the risk factors for infection. The Kirby-Bauer paper diffusion method was used to monitor the Pseudomonas aeruginosa (Schroeter) Migula drug resistance. Results Lower respiratory tract infection was most common in the 97 cases with Pseudomonas aeruginosa (Schroeter) Migula infection in ICU. Pseudomonas aeruginosa (Schroeter) Migula had multi-drug resistant to antibacterial agents and the antibacterial activity of carbapenems-imipenem was the best. Conclusion In ICU, strict disinfection and execute aseptic operation are required to avoid the occurrence of Pseudomonas aeruginosa (Schroeter) Migula infection. A reasonable use of antibiotics should be applied in clinical medication to minimize the genetration of bacterial resistance.