液固壓縮技術(shù)是利用液體賦形劑溶解難溶性藥物，然后用涂層材料吸收后得到固體粉末的一種技術(shù)。該技術(shù)可有效增加生物藥劑學(xué)分類系統(tǒng)（BCS）Ⅱ類水難溶性藥物溶出速率，通過液固壓縮技術(shù)制得的粉末具有良好的流動(dòng)性和可壓性，工藝簡單、成熟。重點(diǎn)介紹液固壓縮技術(shù)的理論基礎(chǔ)、作用機(jī)制和制備方法，并對(duì)液固壓縮技術(shù)在難溶藥物固體制劑和緩控釋制劑中的應(yīng)用進(jìn)行歸納總結(jié)。

Liquisolid technology implies that poorly water soluble drugs carried in suitable non-volatile liquid systems, by simple blending with suitable excipients ‘carrier and coating materials’, can be converted into a free flowing and readily compactible powder. It has been proved to be a promising technology to improve the dissolution rate of poorly water soluble drugs. The objective of this article is to introduce the theory, mechanisms, and preparation method of this new technology, and to summarize its application in the poorly water-soluble drug preparation and controlled-release formulation.

國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃項(xiàng)目（2010CB735602）